Preoperative pancreatic stiffness by real-time tissue elastography to predict pancreatic fistula after pancreaticoduodenectomy

Noboru Harada, Tomoharu Yoshizumi, Takashi Maeda, Hiroto Kayashima, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yoshihiko Maehara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To assess the correlations among pancreatic fibrosis, pancreatic stiffness, and postoperative pancreatic fistula (PF). Patients and Methods: The study population consisted of 17 consecutively enrolled patients who underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD). The liver fibrosis (LF) index as pancreatic stiffness was measured by real- time tissue elastography (RTE) before SSPPD. We also obtained the pathological fibrosis assessment of the pancreatic stump after SSPPD. Results: The LF index was significantly correlated with pathological pancreatic stump fibrosis. The LF index of patients without PF was significantly higher than that of patients with PF. The optimal cut-off value of the LF index to predict postoperative PF was defined as an LF index ≤1.91. Multivariate analysis revealed that a preoperative LF index ≤1.91 was an independent predictive factor of postoperative PF. Conclusion: Evaluation of pancreatic stiffness using RTE might be an objective index to estimate pancreatic fibrosis and predict postoperative PF.

Original languageEnglish
Pages (from-to)1909-1915
Number of pages7
JournalAnticancer research
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Pancreatic Fistula
Elasticity Imaging Techniques
Pancreaticoduodenectomy
Liver Cirrhosis
Fibrosis
Stomach
Multivariate Analysis
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Preoperative pancreatic stiffness by real-time tissue elastography to predict pancreatic fistula after pancreaticoduodenectomy. / Harada, Noboru; Yoshizumi, Tomoharu; Maeda, Takashi; Kayashima, Hiroto; Ikegami, Toru; Harimoto, Norifumi; Itoh, Shinji; Maehara, Yoshihiko.

In: Anticancer research, Vol. 37, No. 4, 04.2017, p. 1909-1915.

Research output: Contribution to journalArticle

@article{1d10c5efdef749a390668215ed7ee1a8,
title = "Preoperative pancreatic stiffness by real-time tissue elastography to predict pancreatic fistula after pancreaticoduodenectomy",
abstract = "Aim: To assess the correlations among pancreatic fibrosis, pancreatic stiffness, and postoperative pancreatic fistula (PF). Patients and Methods: The study population consisted of 17 consecutively enrolled patients who underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD). The liver fibrosis (LF) index as pancreatic stiffness was measured by real- time tissue elastography (RTE) before SSPPD. We also obtained the pathological fibrosis assessment of the pancreatic stump after SSPPD. Results: The LF index was significantly correlated with pathological pancreatic stump fibrosis. The LF index of patients without PF was significantly higher than that of patients with PF. The optimal cut-off value of the LF index to predict postoperative PF was defined as an LF index ≤1.91. Multivariate analysis revealed that a preoperative LF index ≤1.91 was an independent predictive factor of postoperative PF. Conclusion: Evaluation of pancreatic stiffness using RTE might be an objective index to estimate pancreatic fibrosis and predict postoperative PF.",
author = "Noboru Harada and Tomoharu Yoshizumi and Takashi Maeda and Hiroto Kayashima and Toru Ikegami and Norifumi Harimoto and Shinji Itoh and Yoshihiko Maehara",
year = "2017",
month = "4",
doi = "10.21873/anticanres.11529",
language = "English",
volume = "37",
pages = "1909--1915",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "4",

}

TY - JOUR

T1 - Preoperative pancreatic stiffness by real-time tissue elastography to predict pancreatic fistula after pancreaticoduodenectomy

AU - Harada, Noboru

AU - Yoshizumi, Tomoharu

AU - Maeda, Takashi

AU - Kayashima, Hiroto

AU - Ikegami, Toru

AU - Harimoto, Norifumi

AU - Itoh, Shinji

AU - Maehara, Yoshihiko

PY - 2017/4

Y1 - 2017/4

N2 - Aim: To assess the correlations among pancreatic fibrosis, pancreatic stiffness, and postoperative pancreatic fistula (PF). Patients and Methods: The study population consisted of 17 consecutively enrolled patients who underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD). The liver fibrosis (LF) index as pancreatic stiffness was measured by real- time tissue elastography (RTE) before SSPPD. We also obtained the pathological fibrosis assessment of the pancreatic stump after SSPPD. Results: The LF index was significantly correlated with pathological pancreatic stump fibrosis. The LF index of patients without PF was significantly higher than that of patients with PF. The optimal cut-off value of the LF index to predict postoperative PF was defined as an LF index ≤1.91. Multivariate analysis revealed that a preoperative LF index ≤1.91 was an independent predictive factor of postoperative PF. Conclusion: Evaluation of pancreatic stiffness using RTE might be an objective index to estimate pancreatic fibrosis and predict postoperative PF.

AB - Aim: To assess the correlations among pancreatic fibrosis, pancreatic stiffness, and postoperative pancreatic fistula (PF). Patients and Methods: The study population consisted of 17 consecutively enrolled patients who underwent subtotal stomach-preserving pancreaticoduodenectomy (SSPPD). The liver fibrosis (LF) index as pancreatic stiffness was measured by real- time tissue elastography (RTE) before SSPPD. We also obtained the pathological fibrosis assessment of the pancreatic stump after SSPPD. Results: The LF index was significantly correlated with pathological pancreatic stump fibrosis. The LF index of patients without PF was significantly higher than that of patients with PF. The optimal cut-off value of the LF index to predict postoperative PF was defined as an LF index ≤1.91. Multivariate analysis revealed that a preoperative LF index ≤1.91 was an independent predictive factor of postoperative PF. Conclusion: Evaluation of pancreatic stiffness using RTE might be an objective index to estimate pancreatic fibrosis and predict postoperative PF.

UR - http://www.scopus.com/inward/record.url?scp=85017433293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017433293&partnerID=8YFLogxK

U2 - 10.21873/anticanres.11529

DO - 10.21873/anticanres.11529

M3 - Article

C2 - 28373459

AN - SCOPUS:85017433293

VL - 37

SP - 1909

EP - 1915

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 4

ER -