Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance

Tadahiro Nozoe, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential. Methods: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood. Results: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients. Conclusion: All the immunologic parameters can predict the outcome of patients with ESCC.

Original languageEnglish
Pages (from-to)6689-6693
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number42
DOIs
Publication statusPublished - Nov 14 2005

Fingerprint

T-Lymphocytes
CD4-CD8 Ratio
Survival Rate
Esophageal Squamous Cell Carcinoma
Multivariate Analysis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma : Its prognostic significance. / Nozoe, Tadahiro; Maehara, Yoshihiko; Sugimachi, Keizo.

In: World Journal of Gastroenterology, Vol. 11, No. 42, 14.11.2005, p. 6689-6693.

Research output: Contribution to journalArticle

@article{738ef8fa893a4b9e9b2c62cdd8aab817,
title = "Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma: Its prognostic significance",
abstract = "Aim: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential. Methods: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood. Results: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients. Conclusion: All the immunologic parameters can predict the outcome of patients with ESCC.",
author = "Tadahiro Nozoe and Yoshihiko Maehara and Keizo Sugimachi",
year = "2005",
month = "11",
day = "14",
doi = "10.3748/wjg.v11.i42.6689",
language = "English",
volume = "11",
pages = "6689--6693",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "42",

}

TY - JOUR

T1 - Preoperative sorting of circulating T lymphocytes in patients with esophageal squamous cell carcinoma

T2 - Its prognostic significance

AU - Nozoe, Tadahiro

AU - Maehara, Yoshihiko

AU - Sugimachi, Keizo

PY - 2005/11/14

Y1 - 2005/11/14

N2 - Aim: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential. Methods: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood. Results: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients. Conclusion: All the immunologic parameters can predict the outcome of patients with ESCC.

AB - Aim: To elucidate the immunologic parameters for the outcome of patients with malignant tumors, especially esophageal squamous cell carcinoma (ESCC) associated with high malignant potential. Methods: Clinicopathologic features were compared between patients with lower and higher CD4 and CD8 values as well as CD4/CD8 ratio in peripheral blood. Results: The survival rate of patients with higher CD4 value was significantly better than that in patients with lower CD4 value (P = 0.039). The survival rate of patients with higher CD8 value was significantly worse than that of patients with lower CD8 value (P = 0.026). Similarly, the survival rate of patients with higher CD4/CD8 ratio was significantly better than that of patients with lower CD4/CD8 ratio (P = 0.042). Additionally, multivariate analysis demonstrated that lower CD8 and lower CD4/CD8 ratio were factors independently associated with worse prognosis of patients. Conclusion: All the immunologic parameters can predict the outcome of patients with ESCC.

UR - http://www.scopus.com/inward/record.url?scp=30444449407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30444449407&partnerID=8YFLogxK

U2 - 10.3748/wjg.v11.i42.6689

DO - 10.3748/wjg.v11.i42.6689

M3 - Article

C2 - 16425367

AN - SCOPUS:30444449407

VL - 11

SP - 6689

EP - 6693

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 42

ER -