Preparation and biological properties of saccharide-modified gold nanoparticles

Masayuki Toyoshima; Ken Ooya; Yoshiko Miura; Kazukiyo Kobayashi

doi:10.2497/jjspm.54.843

Preparation and biological properties of saccharide-modified gold nanoparticles

Masayuki Toyoshima, Ken Ooya, Yoshiko Miura, Kazukiyo Kobayashi

Research output: Contribution to journal › Article › peer-review

Abstract

The gold nanoparticels were modified by biological active saccharides, and the properties of gold nanoparticle including protein recognition abilities were investigated. First, the gold nanoparticle with a diameter of about 8 nm was modified by lactose-substituted mercapto oligoethylene. The gold nanoparticle was water soluble, and aggregated by addition of the specific recognition lectin. Then, the gold nanoparticle with a diameter of 40 nm was prepared by glycopolymer cattying α-mannoside. The gold nanoparticle with mannose was readily water soluble, and showed pink colour. The UV-adsorption of the gold nanoparticle was increased by addition of the specific recognition lectin of Concanavalin A though other protein didn't change the UV spectra.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy
Volume	54
Issue number	12
DOIs	https://doi.org/10.2497/jjspm.54.843
Publication status	Published - Dec 1 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Mechanical Engineering
Industrial and Manufacturing Engineering
Metals and Alloys
Materials Chemistry

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AB - The gold nanoparticels were modified by biological active saccharides, and the properties of gold nanoparticle including protein recognition abilities were investigated. First, the gold nanoparticle with a diameter of about 8 nm was modified by lactose-substituted mercapto oligoethylene. The gold nanoparticle was water soluble, and aggregated by addition of the specific recognition lectin. Then, the gold nanoparticle with a diameter of 40 nm was prepared by glycopolymer cattying α-mannoside. The gold nanoparticle with mannose was readily water soluble, and showed pink colour. The UV-adsorption of the gold nanoparticle was increased by addition of the specific recognition lectin of Concanavalin A though other protein didn't change the UV spectra.

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Preparation and biological properties of saccharide-modified gold nanoparticles

Abstract

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