Preparation and biological properties of saccharide-modified gold nanoparticles

Masayuki Toyoshima, Ken Ooya, Yoshiko Miura, Kazukiyo Kobayashi

Research output: Contribution to journalArticle

Abstract

The gold nanoparticels were modified by biological active saccharides, and the properties of gold nanoparticle including protein recognition abilities were investigated. First, the gold nanoparticle with a diameter of about 8 nm was modified by lactose-substituted mercapto oligoethylene. The gold nanoparticle was water soluble, and aggregated by addition of the specific recognition lectin. Then, the gold nanoparticle with a diameter of 40 nm was prepared by glycopolymer cattying α-mannoside. The gold nanoparticle with mannose was readily water soluble, and showed pink colour. The UV-adsorption of the gold nanoparticle was increased by addition of the specific recognition lectin of Concanavalin A though other protein didn't change the UV spectra.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalFuntai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy
Volume54
Issue number12
DOIs
Publication statusPublished - Dec 1 2007

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Gold
Nanoparticles
Lectins
Mannosides
Proteins
Water
Lactose
Mannose
Concanavalin A
Color
Adsorption

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering
  • Metals and Alloys
  • Materials Chemistry

Cite this

Preparation and biological properties of saccharide-modified gold nanoparticles. / Toyoshima, Masayuki; Ooya, Ken; Miura, Yoshiko; Kobayashi, Kazukiyo.

In: Funtai Oyobi Fummatsu Yakin/Journal of the Japan Society of Powder and Powder Metallurgy, Vol. 54, No. 12, 01.12.2007, p. 843-848.

Research output: Contribution to journalArticle

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