Preparation and biomedical application of self-organized honeycomb-patterned polymer films

Takahito Kawano; Nagayoshi Iwama; Hiroshi Ishihata; Hidetoshi Shimauchi; Masatsugu Shimomura

doi:10.1007/978-4-431-54070-0_4

Preparation and biomedical application of self-organized honeycomb-patterned polymer films

Takahito Kawano, Nagayoshi Iwama, Hiroshi Ishihata, Hidetoshi Shimauchi, Masatsugu Shimomura

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Citations (Scopus)

Abstract

We found that self organized honeycomb patterned porous polymer films (honeycomb films) prepared by casting polymer dissolved in a water immiscible solvent under high humidity. We demonstrated that the microtopography of the honeycomb film strongly affected human mesenchymal stem cells (hMSCs) and periodontal ligament (PDL) cells, which were the important cell sources for tissue engineering. hMSCs on the honeycomb films having smallsized (1.5 mm) pores induced a dramatic stem cell spheroid formation. PDL cells on the honeycomb films (pore sizes of 10 mm) formed increasingly elongated cell shape to trap in their pores. The honeycomb films, which controlled cellular morphology by changing only the geometric cues without the inducing media, can be applied as functional biomaterials for the regenerative therapy.

Original language	English
Title of host publication	Interface Oral Health Science 2011
Publisher	Springer Japan
Pages	22-26
Number of pages	5
ISBN (Electronic)	9784431540700
ISBN (Print)	9784431540694
DOIs	https://doi.org/10.1007/978-4-431-54070-0_4
Publication status	Published - Jan 1 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Dentistry(all)

Access to Document

10.1007/978-4-431-54070-0_4

Cite this

@inbook{6b5e74f638284411adc5f9c319c9d48b,

title = "Preparation and biomedical application of self-organized honeycomb-patterned polymer films",

abstract = "We found that self organized honeycomb patterned porous polymer films (honeycomb films) prepared by casting polymer dissolved in a water immiscible solvent under high humidity. We demonstrated that the microtopography of the honeycomb film strongly affected human mesenchymal stem cells (hMSCs) and periodontal ligament (PDL) cells, which were the important cell sources for tissue engineering. hMSCs on the honeycomb films having smallsized (1.5 mm) pores induced a dramatic stem cell spheroid formation. PDL cells on the honeycomb films (pore sizes of 10 mm) formed increasingly elongated cell shape to trap in their pores. The honeycomb films, which controlled cellular morphology by changing only the geometric cues without the inducing media, can be applied as functional biomaterials for the regenerative therapy. ",

author = "Takahito Kawano and Nagayoshi Iwama and Hiroshi Ishihata and Hidetoshi Shimauchi and Masatsugu Shimomura",

note = "Publisher Copyright: {\textcopyright} Springer 2012.",

year = "2012",

month = jan,

day = "1",

doi = "10.1007/978-4-431-54070-0_4",

language = "English",

isbn = "9784431540694",

pages = "22--26",

booktitle = "Interface Oral Health Science 2011",

publisher = "Springer Japan",

address = "Japan",

}

TY - CHAP

T1 - Preparation and biomedical application of self-organized honeycomb-patterned polymer films

AU - Kawano, Takahito

AU - Iwama, Nagayoshi

AU - Ishihata, Hiroshi

AU - Shimauchi, Hidetoshi

AU - Shimomura, Masatsugu

PY - 2012/1/1

Y1 - 2012/1/1

N2 - We found that self organized honeycomb patterned porous polymer films (honeycomb films) prepared by casting polymer dissolved in a water immiscible solvent under high humidity. We demonstrated that the microtopography of the honeycomb film strongly affected human mesenchymal stem cells (hMSCs) and periodontal ligament (PDL) cells, which were the important cell sources for tissue engineering. hMSCs on the honeycomb films having smallsized (1.5 mm) pores induced a dramatic stem cell spheroid formation. PDL cells on the honeycomb films (pore sizes of 10 mm) formed increasingly elongated cell shape to trap in their pores. The honeycomb films, which controlled cellular morphology by changing only the geometric cues without the inducing media, can be applied as functional biomaterials for the regenerative therapy.

AB - We found that self organized honeycomb patterned porous polymer films (honeycomb films) prepared by casting polymer dissolved in a water immiscible solvent under high humidity. We demonstrated that the microtopography of the honeycomb film strongly affected human mesenchymal stem cells (hMSCs) and periodontal ligament (PDL) cells, which were the important cell sources for tissue engineering. hMSCs on the honeycomb films having smallsized (1.5 mm) pores induced a dramatic stem cell spheroid formation. PDL cells on the honeycomb films (pore sizes of 10 mm) formed increasingly elongated cell shape to trap in their pores. The honeycomb films, which controlled cellular morphology by changing only the geometric cues without the inducing media, can be applied as functional biomaterials for the regenerative therapy.

UR - http://www.scopus.com/inward/record.url?scp=84884586622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884586622&partnerID=8YFLogxK

U2 - 10.1007/978-4-431-54070-0_4

DO - 10.1007/978-4-431-54070-0_4

M3 - Chapter

AN - SCOPUS:84884586622

SN - 9784431540694

SP - 22

EP - 26

BT - Interface Oral Health Science 2011

PB - Springer Japan

ER -

Preparation and biomedical application of self-organized honeycomb-patterned polymer films

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this