Preparation and blomlnerallzatlon of silica-based organic-inorganic hybrid hollow nanoparticles for bone tissue generation

Song Chen, Akiyoshi Osaka, Kanji Tsuru, Satoshi Hayahawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Novel bioactive silica-based organic-inorganic hollow hybrid particles involving Ca2+ ions for stimulating and inducing bone generation were prepared via a teinplatiiig synthesis route. The solid hybrid nanoparticles were first derived from the core-silica particles and natural polymer shell layers that were composed of chitosan and calcium alginate. They were then soaked in a concentrated NaOH solution and subjected to controlled dissolution of the core-silica, which led to yielding the hollow hybrid particles. The resultant particles were spherical in shape. with the porous surface. The polymer shells suppressed the dissolution behavior o f the core-silica. and thus a partially void structure was formed inside the hybrid particles. An Energy Dispersion Spectroscopic analysis indicated that the polymer shells retained much silica and offered a matrix to maintain the spherical shape ofthe partially hollow particles. When soaked in the Kokubo's simulated body fluid (SBF), the hollow particles deposited apatite crystals within one week. that is, they exhibited strong bioactivity. In contrast, it took one month or longer for the apatite to be deposited on the naked silica particles n ithout the polymer shell coatings layers. Thus. Ca in the hollow particles significantly accelerated apatite formation. Therefore, the present organic-inorganic hollow particles could be a promising candidate for bone regeneration drug or factor carriers.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Porous Ceramics - A Collection of Papers Presented at the 32nd International Conference on Advanced Ceramics and Composites, ICACC 2008
Pages19-26
Number of pages8
Volume29
Edition7
Publication statusPublished - 2009
Externally publishedYes
EventAdvances in Bioceramics and Porous Ceramics - 32nd International Conference on Advanced Ceramics and Composites, ICACC 2008 - Daytona Beach, FL, United States
Duration: Jan 27 2008Feb 1 2008

Other

OtherAdvances in Bioceramics and Porous Ceramics - 32nd International Conference on Advanced Ceramics and Composites, ICACC 2008
CountryUnited States
CityDaytona Beach, FL
Period1/27/082/1/08

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

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