Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor

Yasuhiro Maeda, Akira Matsumoto, Yoshiko Miura, Yuji Miyahara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET.

Original languageEnglish
Article number108
Pages (from-to)1-9
Number of pages9
JournalNanoscale Research Letters
Volume7
DOIs
Publication statusPublished - Mar 8 2012

Fingerprint

Mannosides
Gates (transistor)
Hydrogel
carbohydrates
Hydrogels
field effect transistors
Gels
gels
proteins
Proteins
preparation
Concanavalin A
Field effect transistors
Lectins
interactions
Polymers
polymers
Carbohydrates
swelling
Swelling

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor. / Maeda, Yasuhiro; Matsumoto, Akira; Miura, Yoshiko; Miyahara, Yuji.

In: Nanoscale Research Letters, Vol. 7, 108, 08.03.2012, p. 1-9.

Research output: Contribution to journalArticle

@article{eb81358a959247479c2fa198fc5ef545,
title = "Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor",
abstract = "The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET.",
author = "Yasuhiro Maeda and Akira Matsumoto and Yoshiko Miura and Yuji Miyahara",
year = "2012",
month = "3",
day = "8",
doi = "10.1186/1556-276X-7-108",
language = "English",
volume = "7",
pages = "1--9",
journal = "Nanoscale Research Letters",
issn = "1931-7573",
publisher = "Springer New York",

}

TY - JOUR

T1 - Preparation of α-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor

AU - Maeda, Yasuhiro

AU - Matsumoto, Akira

AU - Miura, Yoshiko

AU - Miyahara, Yuji

PY - 2012/3/8

Y1 - 2012/3/8

N2 - The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET.

AB - The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between 'pendant' carbohydrate and a 'target' lectin concanavalin A [Con A] was synthesized. It was revealed that direction and magnitude of the gel response (swelling or deswelling) could be readily designed depending on composition and network density of the gel. The Con A-sensitive polymer gel has shown the ability to transduce the detection of saccharide-protein interactions into electrical signals for FET.

UR - http://www.scopus.com/inward/record.url?scp=84857725370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857725370&partnerID=8YFLogxK

U2 - 10.1186/1556-276X-7-108

DO - 10.1186/1556-276X-7-108

M3 - Article

VL - 7

SP - 1

EP - 9

JO - Nanoscale Research Letters

JF - Nanoscale Research Letters

SN - 1931-7573

M1 - 108

ER -