Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

Tomohiko Yoshioka; Kanji Tsuru; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.1016/S0142-9612(03)00127-3

Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

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72 Citations (Scopus)

Abstract

This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.

Original language	English
Pages (from-to)	2889-2894
Number of pages	6
Journal	Biomaterials
Volume	24
Issue number	17
DOIs	https://doi.org/10.1016/S0142-9612(03)00127-3
Publication status	Published - Aug 2003

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/S0142-9612(03)00127-3

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title = "Preparation of alginic acid layers on stainless-steel substrates for biomedical applications",

abstract = "This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.",

author = "Tomohiko Yoshioka and Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka",

note = "Funding Information: The authors thank Professor Hidenori Yamada of Okayama University for his helpful discussion. This study was supported by the Industrial Technology Research Grant Program (02A47022a) in {\textquoteleft}02 from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.",

year = "2003",

month = aug,

doi = "10.1016/S0142-9612(03)00127-3",

language = "English",

volume = "24",

pages = "2889--2894",

journal = "Biomaterials",

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T1 - Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

AU - Yoshioka, Tomohiko

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

N1 - Funding Information: The authors thank Professor Hidenori Yamada of Okayama University for his helpful discussion. This study was supported by the Industrial Technology Research Grant Program (02A47022a) in ‘02 from the New Energy and Industrial Technology Development Organization (NEDO) of Japan.

PY - 2003/8

Y1 - 2003/8

N2 - This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.

AB - This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.

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U2 - 10.1016/S0142-9612(03)00127-3

DO - 10.1016/S0142-9612(03)00127-3

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AN - SCOPUS:0038755161

SN - 0142-9612

VL - 24

SP - 2889

EP - 2894

JO - Biomaterials

JF - Biomaterials

IS - 17

ER -

Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

Abstract

All Science Journal Classification (ASJC) codes

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