Preparation of artificial glycolipids and their aggregation behavior in aqueous media

Yoshio Hisaeda, Eiji Ohshima, Jun Ichi Kikuchi, Yukito Murakami

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.

Original languageEnglish
Pages (from-to)6713-6716
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number38
DOIs
Publication statusPublished - Sep 22 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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