Preparation of artificial glycolipids and their aggregation behavior in aqueous media

Yoshio Hisaeda, Eiji Ohshima, Jun Ichi Kikuchi, Yukito Murakami

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    N,N-Dihexadecyl-N(α)-[6-(β-D-galactopyranosyl)hexanoyl]-L-alaninamide and N,N- dihexadecyl-N(α)-[6{(β-D-galactopyranosyl)-(1→4)-O-(D -glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino acid residue interposed between a polar sugar moiety and a hydrophobic double-chain segment individually, were prepared and characterized as novel artificial glycolipids. Morphological studies by means of differential scanning calorimetry and dynamic light scattering as well as electron microscopy clarified that these lipids tend to form stable bilayer membranes by themselves in aqueous media.

    Original languageEnglish
    Pages (from-to)6713-6716
    Number of pages4
    JournalTetrahedron Letters
    Volume38
    Issue number38
    DOIs
    Publication statusPublished - Sep 22 1997

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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