Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering

Minoru Kawaguchi, Tadao Fukushima, Toru Hayakawa, Naotoshi Nakashima, Yusuke Inoue, Shoji Takeda, Kazuhiko Okamura, Kunihisa Taniguchi

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

A novel scaffold material based on an alginate hydrogel which contained carbon nanotubes (CNTs) was prepared, and its mechanical property and biocompatibility evaluated. Soluble CNTs were prepared with acid treatment and dispersed in sodium alginate solution as a cross-linker. After which, the mechanical property (elastic deformation), saline sorption, histological reaction, and cell viability of the resultant nanocomposite gel (CNT-Alg gel) were evaluated. The CNT-Alg gel showed faster gelling and higher mechanical strength than the conventional alginate gel. Saline sorption amount of freeze-dried CNT-Alg gel was equal to that of the alginate gel. In terms of histological evaluation and cell viability assay, CNT-Alg gel exhibited a mild inflammatory response and non-cytotoxicity. These results thus suggested that CNT-Alg gel could be useful as a scaffold material in tissue engineering with the sidewalls of CNTs acting as active sites for chemical functionalization.

Original languageEnglish
Pages (from-to)719-725
Number of pages7
Journaldental materials journal
Volume25
Issue number4
DOIs
Publication statusPublished - Jan 1 2006

Fingerprint

Nanocomposites
Carbon Nanotubes
Alginate
Tissue Engineering
Tissue engineering
Carbon nanotubes
Gels
Scaffolds (biology)
Sorption
Cell Survival
Cells
Sodium alginate
Mechanical properties
alginic acid
Hydrogel
Elastic deformation
Biocompatibility
Hydrogels
Strength of materials
Assays

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)

Cite this

Kawaguchi, M., Fukushima, T., Hayakawa, T., Nakashima, N., Inoue, Y., Takeda, S., ... Taniguchi, K. (2006). Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering. dental materials journal, 25(4), 719-725. https://doi.org/10.4012/dmj.25.719

Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering. / Kawaguchi, Minoru; Fukushima, Tadao; Hayakawa, Toru; Nakashima, Naotoshi; Inoue, Yusuke; Takeda, Shoji; Okamura, Kazuhiko; Taniguchi, Kunihisa.

In: dental materials journal, Vol. 25, No. 4, 01.01.2006, p. 719-725.

Research output: Contribution to journalArticle

Kawaguchi, M, Fukushima, T, Hayakawa, T, Nakashima, N, Inoue, Y, Takeda, S, Okamura, K & Taniguchi, K 2006, 'Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering', dental materials journal, vol. 25, no. 4, pp. 719-725. https://doi.org/10.4012/dmj.25.719
Kawaguchi M, Fukushima T, Hayakawa T, Nakashima N, Inoue Y, Takeda S et al. Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering. dental materials journal. 2006 Jan 1;25(4):719-725. https://doi.org/10.4012/dmj.25.719
Kawaguchi, Minoru ; Fukushima, Tadao ; Hayakawa, Toru ; Nakashima, Naotoshi ; Inoue, Yusuke ; Takeda, Shoji ; Okamura, Kazuhiko ; Taniguchi, Kunihisa. / Preparation of carbon nanotube-alginate nanocomposite gel for tissue engineering. In: dental materials journal. 2006 ; Vol. 25, No. 4. pp. 719-725.
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