TY - JOUR
T1 - Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application
AU - Kim, Hyung Il
AU - Matsuno, Ryosuke
AU - Seo, Ji Hun
AU - Konno, Tomohiro
AU - Takai, Madoka
AU - Ishihara, Kazuhiko
N1 - Funding Information:
This work was supported in part by Global-COE Program, Center for Medical System Innovation, MEXT, Japan.
PY - 2009/7
Y1 - 2009/7
N2 - Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.
AB - Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.
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U2 - 10.1016/j.cap.2009.06.001
DO - 10.1016/j.cap.2009.06.001
M3 - Article
AN - SCOPUS:71849087382
SN - 1567-1739
VL - 9
SP - e249-e251
JO - Current Applied Physics
JF - Current Applied Physics
IS - 4 SUPPL.
ER -