Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source

Kazunobu Igawa, Yuuya Kawasaki, Yusuke Ano, Takeru Kashiwagi, Kouhei Ogawa, Jun Ichi Hayashi, Ryota Morita, Yukari Yoshioka, Kazuhiro Uehara, Katsuhiko Tomooka

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Abstract

To obtain enantioenriched chiral organic molecules, numerous optical resolution and asymmetric synthetic methods have been developed to date. Herein, we introduce a new approach termed dynamic asymmetric induction (DYASIN) for the preparation of enantioenriched chiral molecules based on the stereocontrol of dynamic chiral molecules (DYCMs) using an outer chiral source (OCS). DYASIN makes it possible to obtain the enantioenriched form of dynamic chiral molecules from their racemic form without bond cleavage or bond formation. The thus-obtained enantioenriched molecules can be readily converted into a variety of chiral molecules with stable stereochemistries, without any loss of enantiomeric purity.

Original languageEnglish
Pages (from-to)726-729
Number of pages4
JournalChemistry Letters
Volume48
Issue number7
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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    Igawa, K., Kawasaki, Y., Ano, Y., Kashiwagi, T., Ogawa, K., Hayashi, J. I., Morita, R., Yoshioka, Y., Uehara, K., & Tomooka, K. (2019). Preparation of enantioenriched chiral organic molecules by dynamic asymmetric induction from a outer chiral source. Chemistry Letters, 48(7), 726-729. https://doi.org/10.1246/cl.190170