Preparation of glycopolymer-substituted gold nanoparticles and their molecular recognition

Masayuki Toyoshima, Yoshiko Miura

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Glycopolymer-substituted gold nanoparticles were prepared via living radical polymerization with a reversible addition-fragmentation chain transfer (RAFT) reagent. Polyacrylamide derivatives with α-mannose (α-Man) and AT-acetyl-/?glucosamine (β-GlcNAc) were synthesized and hydrogenated to obtain thiol-terminated polymer. The thiol-terminated glycopolymers were mixed with gold nanoparticles to yield the polymer substituted gold nanoparticles with various diameters, which aggregated on addition of saccharide-recognition proteins (lectins). The aggregation properties were analyzed using transmission electron microscopy and UV spectra. Molecular recognition was studied with E. coli, which induced aggregation of the nanoparticles at the cell periphery.

Original languageEnglish
Pages (from-to)1412-1421
Number of pages10
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Issue number5
Publication statusPublished - Mar 1 2009
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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