Preparation of perfluorocarbon/fluoroalkyl polymer nanodroplets for cancer-targeted ultrasound contrast agents

Masamichi Nishihara, Kenji Imai, Masayuki Yokoyama

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Perfluorocarbon (PFC) nanodroplets formed from PEG-bpoly(fluoroheptyl aspartate) were developed for a cancer-targeted ultrasound (US) contrast agent. 10% esterifed fluoroalkyl polymer (F10) was the optimal composition for PFC solubilization in aqueous solution. PFC/F10 nanodroplets showed echogenicity with US irradiation, and long-term stability of PFC nanodroplets at 4 °C was confirmed.

Original languageEnglish
Pages (from-to)556-557
Number of pages2
JournalChemistry Letters
Volume38
Issue number6
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Fluorocarbons
Contrast Media
Polymers
Ultrasonics
Aspartic Acid
Polyethylene glycols
Irradiation
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Preparation of perfluorocarbon/fluoroalkyl polymer nanodroplets for cancer-targeted ultrasound contrast agents. / Nishihara, Masamichi; Imai, Kenji; Yokoyama, Masayuki.

In: Chemistry Letters, Vol. 38, No. 6, 2009, p. 556-557.

Research output: Contribution to journalArticle

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