Preparation of polymer aptamer from a copolymer library

Synthetic polymer aptamers are expected as robust and inexpensive substitute for biomacromolecular ligands. However, in contrast to biomacromolecular ligands, synthetic polymers, which are prepared through onepot chain reaction, result in heterogeneous sequences and structures with a distribution of recognition sites. To obtain polymer aptamers with strong and specific binding affinity to target molecules, strategies to design and produce polymer aptamers with defined structure have to be developed. This article provides a brief review about recent efforts to develop the polymer aptamers consisting of combination of functional acrylamides.