Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

Akiko Sakai, Alireza Valanezahad, Masao Ozaki, Kunio Ishikawa, Shigeki Matsuya

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr 2+ ion substituted Ca 2+ ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
Journaldental materials journal
Issue number2
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)


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