Preparation of superparamagnetic β-cyclodextrin-functionalized composite nanoparticles with core-shell structures

Ruixue Li, Shumei Liu, Jianqing Zhao, Hideyuki Otsuka, Atsushi Takahara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

In this article, we report an original and feasible protocol for the preparation of superparamagnetic β-cyclodextrin-functionalized composite nanoparticles with core-shell structures via cross linking reaction on the surface of carboxymethyl β-cyclodextrin-modified magnetite (Fe 3O4) nanoparticles by using epichlorohydrin as a crosslinking agent. The structure and morphology of the prepared composite nanoparticles were studied by Fourier transform infrared spectrometry, X-ray diffraction measurement, transmission electron microscopy and the thermogravimetric analysis. The results show that the prepared roughly spherical composite nanoparticles (diameter about 10-20 nm) with core-shell structures turned out to be magnetite nanoparticles surface-surrounded by a layer of cross-linked CM-β-cyclodextrin polymer. Results of vibrating sample magnetometry testing and inclusive behaviour studying confirmed the superparamagnetism with saturation magnetization value of 52.0 emu/g in an external applied magnetic field of 20000 Oe and inclusion functionality of the composite nanoparticles consisting of magnetite cores and β-cyclodextrin moiety, which implies very important applications in targeting drug delivery technology and separation for specific substances.

Original languageEnglish
Pages (from-to)1125-1136
Number of pages12
JournalPolymer Bulletin
Volume66
Issue number8
DOIs
Publication statusPublished - May 1 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Polymers and Plastics
  • Materials Chemistry

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