Presence of active hepatitis associated with liver cirrhosis is a risk factor for mortality caused by posthepatectomy liver failure

Hidetoshi Eguchi, Koji Umeshita, Masato Sakon, Hiroaki Nagano, Yasuhiro Ito, Shin Ichi Kishimoto, Keizo Dono, Shoji Nakamori, Tsutomu Takeda, Mitsukazu Gotoh, Kenichi Wakasa, Nariaki Matsuura, Morito Monden

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The histologic activity of associated hepatitis was examined in 285 patients who underwent hepatectomy for hepatocellular carcinoma (HCC), to determine if the histologic activity is an independent risk factor for postoperative mortality due to liver failure. The proportion of patients with liver cirrhosis who died due to liver failure (6/180, 3.3%) was not different from that of patients with chronic hepatitis (2/68, 2.9%). However, mortality was higher in patients with liver cirrhosis and active hepatitis (4/46, 8.7%) than in those with cirrhosis and inactive hepatitis (2/134, 1.5%, P < 0.05). Such difference was not observed in the chronic hepatitis group. Multivariate analysis showed that clearance of indocyanine green at 15 min (ICGR15) and activity of hepatitis were two independent risk factors for postoperative mortality due to liver failure. In conclusion, histologic activity of associated hepatitis should be taken into account in hepatic resection of HCC in cirrhotic liver, in addition to the functional reserve of the liver.

Original languageEnglish
Pages (from-to)1383-1388
Number of pages6
JournalDigestive Diseases and Sciences
Issue number7
Publication statusPublished - Aug 31 2000


All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

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