Presence of interleukin-4-producing cells for human bone regeneration after application of guided tissue regeneration membranes

Kengo Nagata

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

To study the process of bone regeneration we examined three samples of periapical regenerative tissue obtained from two patients under a guided tissue regeneration treatment in endodontic surgery by the immunohistochemical and enzyme histochemical methods. The regenerative tissue consisted of a large number of fibroblast-like cells and a small number of mononuclear cells. Fibroblast-like cells stained positively for alkaline phosphatase and osteopontin, whereas mononuclear cells stained positively for CD4. Interleukin-4-producing cells could be detected in adjacent sections. However, interferon-γ-producing cells could not be detected. These findings suggest that interleukin-4-producing cells may be one of the elements associated with success in the human bone regeneration process in vivo.

Original languageEnglish
Pages (from-to)444-448
Number of pages5
JournalJournal of Endodontics
Volume27
Issue number7
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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