Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation

Ryoichi Takayanagi, Kazuhiro Kitazumi, Chikahisa Takasaki, Keizo Ohnaka, Saburo Aimoto, Kenjí Tasaka, Masao Ohashi, Hajime Nawata

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Abstract

We studied the role of non-selective type (ET14) of endothelin (ET) receptor in the vasculature, using a ligand specific to the ET14 receptor, [Glu9]-sarafotoxin S6b ([Glu9]SRTb). Endothelium-containing rat thoracic aorta possessed specific binding sites for 125I-[Glu9]SRTb, which were almost eliminated by removal of the endothelium, while ET-3-specific binding sites were not detected in the endothelium-intact rat aorta. Only ET14 receptor was detected in the membranes from the endothelium of porcine thoracic aorta. [Glu9]SRTb exerted only vasodilation in rat aortic ring. These findings indicate that ET14 receptors are located on vascular endothelium and linked to vasodilation.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalFEBS Letters
Volume282
Issue number1
DOIs
Publication statusPublished - Apr 22 1991
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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