Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand

Takahiko Horiuchi, Hirota Fujiki, Mitsuru Hirota, Maitree Suttajit, Masami Suganuma, Akiko Yoshioka, Vichai Wongchai, Erich Hecker, Takashi Sugimura

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The seed oil of Jatropha curcas L. was shown to contain skin tumor promoters in a two-stage mouse carcinogenesis experiment. By using the irritant test on mouse ear to monitor activity, the "irritant fraction" was partially purified from the methanol extract of the seed oil by column chromatographies on Florisil and Sephades LH-20. The irritant fraction obtained induced ornithine decarboxylase in mouse skin and inhibited the specific binding of 3H-12-O-tetradecanoylphorbol-13-acetate to a particulate fraction of mouse skin. After initiation with 7,12-dimethylbenz[a]anthracene (DMBA), this "irritant fraction" induced tumors in the skin of 36% of the mice tested in 30 weeks. Tumor incidences in the groups treated with DMBA alone and "irritant fraction" alone were 7% and 13% in week 30, respectively. Since the skin of Thai people comes into direct contact with this seed oil, an epidemiological study on human skin cancer in Thailand is indicated.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalJapanese Journal of Cancer Research
Volume78
Issue number3
Publication statusPublished - Mar 1 1987
Externally publishedYes

Fingerprint

Jatropha
Irritants
Thailand
Carcinogens
Seeds
Oils
Skin
9,10-Dimethyl-1,2-benzanthracene
Ornithine Decarboxylase
Skin Neoplasms
Tetradecanoylphorbol Acetate
Ear
Methanol
Chromatography
Epidemiologic Studies
Neoplasms
Carcinogenesis
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Horiuchi, T., Fujiki, H., Hirota, M., Suttajit, M., Suganuma, M., Yoshioka, A., ... Sugimura, T. (1987). Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. Japanese Journal of Cancer Research, 78(3), 223-226.

Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. / Horiuchi, Takahiko; Fujiki, Hirota; Hirota, Mitsuru; Suttajit, Maitree; Suganuma, Masami; Yoshioka, Akiko; Wongchai, Vichai; Hecker, Erich; Sugimura, Takashi.

In: Japanese Journal of Cancer Research, Vol. 78, No. 3, 01.03.1987, p. 223-226.

Research output: Contribution to journalArticle

Horiuchi, T, Fujiki, H, Hirota, M, Suttajit, M, Suganuma, M, Yoshioka, A, Wongchai, V, Hecker, E & Sugimura, T 1987, 'Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand', Japanese Journal of Cancer Research, vol. 78, no. 3, pp. 223-226.
Horiuchi T, Fujiki H, Hirota M, Suttajit M, Suganuma M, Yoshioka A et al. Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. Japanese Journal of Cancer Research. 1987 Mar 1;78(3):223-226.
Horiuchi, Takahiko ; Fujiki, Hirota ; Hirota, Mitsuru ; Suttajit, Maitree ; Suganuma, Masami ; Yoshioka, Akiko ; Wongchai, Vichai ; Hecker, Erich ; Sugimura, Takashi. / Presence of tumor promoters in the seed oil of Jatropha curcas L. from Thailand. In: Japanese Journal of Cancer Research. 1987 ; Vol. 78, No. 3. pp. 223-226.
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