Presynaptic and Ca2+-independent PKC subspecies modulates NMDAR1 current

Tsuneyuki Koga, Norio Sakai, Chikako Tanaka, Naoaki Saito

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

WE have studied the properties of the protein kinase C (PKC) subspecies that modulates the NMDA receptor (NMDAR1). The current through homomeric NMDAR1 expressed in Xenopus oocytes was increased by 200-500% by phorbol ester and also by activation of a metabotropic glutamate receptor (mGluR1) expressed in the same oocytes. This potentiation of the NMDAR1 current was not inhibited by the intracellular injection of EGTA. Intracellular injection of ε-PKC, a presynaptic PKC subspecies, potentiated the NMDAR1 current more efficiently than did the Ca2+-dependent γ-PKC, a postsynaptic subspecies of the enzyme. Our findings suggested that the presynaptic NMDA receptor could be potentiated in a Ca2+-independent manner by the activation of presynaptic PKC subspecies.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalNeuroReport
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

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Protein Kinase C
N-Methyl-D-Aspartate Receptors
Oocytes
Presynaptic Receptors
Injections
Metabotropic Glutamate Receptors
Egtazic Acid
Phorbol Esters
Xenopus
NMDA receptor A1
Enzymes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Presynaptic and Ca2+-independent PKC subspecies modulates NMDAR1 current. / Koga, Tsuneyuki; Sakai, Norio; Tanaka, Chikako; Saito, Naoaki.

In: NeuroReport, Vol. 7, No. 2, 01.01.1996, p. 477-480.

Research output: Contribution to journalArticle

Koga, Tsuneyuki ; Sakai, Norio ; Tanaka, Chikako ; Saito, Naoaki. / Presynaptic and Ca2+-independent PKC subspecies modulates NMDAR1 current. In: NeuroReport. 1996 ; Vol. 7, No. 2. pp. 477-480.
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