TY - JOUR
T1 - Pretransplant administration of imatinib for allo-HSCT in patients with BCR-ABL-positive acute lymphoblastic leukemia
AU - Mizuta, Shuichi
AU - Matsuo, Keitaro
AU - Nishiwaki, Satoshi
AU - Imai, Kiyotoshi
AU - Kanamori, Heiwa
AU - Ohashi, Kazuteru
AU - Fukuda, Takahiro
AU - Onishi, Yasushi
AU - Miyamura, Koichi
AU - Takahashi, Satoshi
AU - Onizuka, Makoto
AU - Atsuta, Yoshiko
AU - Suzuki, Ritsuro
AU - Morishima, Yasuo
AU - Kato, Koji
AU - Sakamaki, Hisashi
AU - Tanaka, Junji
PY - 2014/4/10
Y1 - 2014/4/10
N2 - We aimed to evaluate the impact of pretransplant imatinib administration on the outcome of allogeneic hematopoietic stem cell transplantation(allo-HSCT) in adults with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We retrospectively analyzed 738 patients with Ph+ ALL that underwent allo-HSCT between 1990 and 2010 using data from the Transplant Registry Unified Management Program of the Japan Society of Hematopoietic Cell Transplantation. We compared the allo-HSCT outcomes between 542 patients who received imatinib before allo-HSCT during the initial complete remission period (imatinib cohort) and 196 patients who did not receive imatinib (non-imatinib cohort). The 5-year overall survival after allo-HSCT was significantly higher in the imatinib cohort than in the non-imatinib cohort (59% vs 38%; 95% confidence interval [CI], 31-45%; P < .001). Multivariate analysis indicated that pretransplant imatinib administration had beneficial effects on overall survival (hazardratio [HR], 0.57; 95%CI, 0.42-0.77; P < .001), relapse (HR, 0.66; 95% CI, 0.43-0.99; P = .048), and nonrelapse mortality (HR, 0.55; 95% CI, 0.37-0.83; P = .005). In conclusion, our study showed that imatinib administration before allo-HSCT had advantageous effects on the clinical outcomes of allo-HSCT in patients with Ph+ ALL.
AB - We aimed to evaluate the impact of pretransplant imatinib administration on the outcome of allogeneic hematopoietic stem cell transplantation(allo-HSCT) in adults with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). We retrospectively analyzed 738 patients with Ph+ ALL that underwent allo-HSCT between 1990 and 2010 using data from the Transplant Registry Unified Management Program of the Japan Society of Hematopoietic Cell Transplantation. We compared the allo-HSCT outcomes between 542 patients who received imatinib before allo-HSCT during the initial complete remission period (imatinib cohort) and 196 patients who did not receive imatinib (non-imatinib cohort). The 5-year overall survival after allo-HSCT was significantly higher in the imatinib cohort than in the non-imatinib cohort (59% vs 38%; 95% confidence interval [CI], 31-45%; P < .001). Multivariate analysis indicated that pretransplant imatinib administration had beneficial effects on overall survival (hazardratio [HR], 0.57; 95%CI, 0.42-0.77; P < .001), relapse (HR, 0.66; 95% CI, 0.43-0.99; P = .048), and nonrelapse mortality (HR, 0.55; 95% CI, 0.37-0.83; P = .005). In conclusion, our study showed that imatinib administration before allo-HSCT had advantageous effects on the clinical outcomes of allo-HSCT in patients with Ph+ ALL.
UR - http://www.scopus.com/inward/record.url?scp=84899099018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899099018&partnerID=8YFLogxK
U2 - 10.1182/blood-2013-11-538728
DO - 10.1182/blood-2013-11-538728
M3 - Article
C2 - 24591204
AN - SCOPUS:84899099018
SN - 0006-4971
VL - 123
SP - 2325
EP - 2332
JO - Blood
JF - Blood
IS - 15
ER -