Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

Tomohiro Yubi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Yoichiro Hirakawa, Daigo Yoshida, Seiji Gotoh, Naoki Hirabayashi, Yoshihiko Furuta, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ϵ4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers. Conclusions Our study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalNeurology: Clinical Practice
Volume8
Issue number3
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Cross-Sectional Studies
Logistic Models
Cholesterol
Regression Analysis
Hypertension
Health
Brain
Serum
Population

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community. / Yubi, Tomohiro; Hata, Jun; Ohara, Tomoyuki; Mukai, Naoko; Hirakawa, Yoichiro; Yoshida, Daigo; Gotoh, Seiji; Hirabayashi, Naoki; Furuta, Yoshihiko; Ago, Tetsuro; Kitazono, Takanari; Kiyohara, Yutaka; Ninomiya, Toshiharu.

In: Neurology: Clinical Practice, Vol. 8, No. 3, 01.06.2018, p. 223-231.

Research output: Contribution to journalReview article

@article{29eb2ecc30ab45c3b02408c1fadf43d5,
title = "Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community",
abstract = "Background We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7{\%} (n = 240), 13.5{\%} (n = 173), and 9.6{\%} (n = 123), respectively. The prevalence of total CMBs was 23.0{\%} in men and 15.5{\%} in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ϵ4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers. Conclusions Our study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.",
author = "Tomohiro Yubi and Jun Hata and Tomoyuki Ohara and Naoko Mukai and Yoichiro Hirakawa and Daigo Yoshida and Seiji Gotoh and Naoki Hirabayashi and Yoshihiko Furuta and Tetsuro Ago and Takanari Kitazono and Yutaka Kiyohara and Toshiharu Ninomiya",
year = "2018",
month = "6",
day = "1",
doi = "10.1212/CPJ.0000000000000464",
language = "English",
volume = "8",
pages = "223--231",
journal = "Neurology: Clinical Practice",
issn = "2163-0402",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community

AU - Yubi, Tomohiro

AU - Hata, Jun

AU - Ohara, Tomoyuki

AU - Mukai, Naoko

AU - Hirakawa, Yoichiro

AU - Yoshida, Daigo

AU - Gotoh, Seiji

AU - Hirabayashi, Naoki

AU - Furuta, Yoshihiko

AU - Ago, Tetsuro

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

AU - Ninomiya, Toshiharu

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ϵ4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers. Conclusions Our study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.

AB - Background We investigated the prevalence of and risk factors for cerebral microbleeds (CMBs) in a cross-sectional study of a general population of Japanese elderly. Methods In 2012, brain MRI scanning at 1.5T and comprehensive health examination were conducted for 1281 residents aged 65 years or older. CMBs were defined as ovoid hypointensity lesions less than 10 mm in diameter on T2-weighted images and classified into deep/infratentorial or lobar CMBs. Age- and sex-specific and overall prevalence of CMBs were estimated, and the associations of traditional cardiovascular risk factors and APOE polymorphism with the presence of CMBs were examined using a logistic regression analysis. Results The crude prevalences of total, deep/infratentorial, and lobar CMBs were 18.7% (n = 240), 13.5% (n = 173), and 9.6% (n = 123), respectively. The prevalence of total CMBs was 23.0% in men and 15.5% in women and increased with aging in both sexes (both p for trend <0.01). Hypertension was significantly associated with the presence of both deep/infratentorial and lobar CMBs. Lower serum total cholesterol was a significant risk factor for deep/infratentorial CMBs, but not for lobar CMBs, while APOE ϵ4 carriers had a significantly higher likelihood only of lobar CMBs compared with noncarriers. Conclusions Our study suggests that approximately 1 of 5 Japanese elderly people have CMBs, and that risk factors for deep/infratentorial and lobar CMBs are different, indicating the distinct pathologic backgrounds of these lesions.

UR - http://www.scopus.com/inward/record.url?scp=85054026950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054026950&partnerID=8YFLogxK

U2 - 10.1212/CPJ.0000000000000464

DO - 10.1212/CPJ.0000000000000464

M3 - Review article

VL - 8

SP - 223

EP - 231

JO - Neurology: Clinical Practice

JF - Neurology: Clinical Practice

SN - 2163-0402

IS - 3

ER -