Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients

Relationship with C-reactive protein and albuminuria

A. Kuroe, A. Taniguchi, A. Sekiguchi, M. Ogura, Y. Murayama, Fusanori Nishimura, Y. Iwamoto, Y. Seino, S. Nagasaka, M. Fukushima, Y. Soga, Y. Nakai

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of the present study was to investigate the relationship between periodontal bacteria infection (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedius) and C-reactive protein (CRP) and albuminuria in non-obese Japanese type 2 diabetic patients. One hundred and thirty-four non-obese Japanese type 2 diabetic patients without evidence of current acute illness including clinically significant acute infectious disease were enrolled into the study. The degree of periodontal bacterial infection was evaluated using IgG titer against Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, or Prevotella intermedius. The bacterial sonic extracts were used as antigens. High-sensitivity CRP (hCRP), glucose, glycosylated hemoglobin (HbA 1c), and lipids were also measured after an overnight fast. Urinary albumin excretion rate as a ratio of urinary albumin and urinary creatinine was assessed in a morning spot urine sample using a commercial enzymatic immunoassay. The prevalence of Porphyromonas gingivalis infection was 52.2% and that of Actinobacillus actinomycetemcomitans and Prevotella intermedius was 7.5 and 14.2%, respectively. IgG titer against Porphyromonas gingivalis significantly correlated with CRP (r = 0.225, p < 0.001) and albuminuria (r = 0.185, p < 0.05), while IgG titer against Actinobacillus actinomycetemcomitans or Prevotella intermedius was not associated with either parameter. These results suggest that among periodontal bacteria, Porphyromonas gingivalis infection is associated with atherosclerosis in non-obese Japanese type 2 diabetic patients.

Original languageEnglish
Pages (from-to)116-118
Number of pages3
JournalHormone and Metabolic Research
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 1 2004

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Porphyromonas gingivalis
Albuminuria
Prevotella
Aggregatibacter actinomycetemcomitans
Bacterial Infections
C-Reactive Protein
Immunoglobulin G
Albumins
Bacteria
Glycosylated Hemoglobin A
Infection
Creatinine
Lipids
Antigens
Glucose
Acute Disease
Immunoassay
Communicable Diseases
Atherosclerosis
Urine

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients : Relationship with C-reactive protein and albuminuria. / Kuroe, A.; Taniguchi, A.; Sekiguchi, A.; Ogura, M.; Murayama, Y.; Nishimura, Fusanori; Iwamoto, Y.; Seino, Y.; Nagasaka, S.; Fukushima, M.; Soga, Y.; Nakai, Y.

In: Hormone and Metabolic Research, Vol. 36, No. 2, 01.02.2004, p. 116-118.

Research output: Contribution to journalArticle

Kuroe, A, Taniguchi, A, Sekiguchi, A, Ogura, M, Murayama, Y, Nishimura, F, Iwamoto, Y, Seino, Y, Nagasaka, S, Fukushima, M, Soga, Y & Nakai, Y 2004, 'Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: Relationship with C-reactive protein and albuminuria', Hormone and Metabolic Research, vol. 36, no. 2, pp. 116-118. https://doi.org/10.1055/s-2004-814221
Kuroe, A. ; Taniguchi, A. ; Sekiguchi, A. ; Ogura, M. ; Murayama, Y. ; Nishimura, Fusanori ; Iwamoto, Y. ; Seino, Y. ; Nagasaka, S. ; Fukushima, M. ; Soga, Y. ; Nakai, Y. / Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients : Relationship with C-reactive protein and albuminuria. In: Hormone and Metabolic Research. 2004 ; Vol. 36, No. 2. pp. 116-118.
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