Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assemble monolayer

Toshikazu Kawaguchi, Hiroyuki Iwasaka, Kiyoshi Matsumoto, Kiyoshi Toko, Norio Miura

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1 Citation (Scopus)


Poly (dimethylsiloxane) (PDMS) is meant to be utilized for a miniaturized sensor system. However, protein and biospecies often adsorb onto a PDMS surface nonspecifically. This matter is a serious challenge in the study of miniaturized sensor systems. We provide the solution, which is a prevention technique of nonspecific adsorption onto a PDMS microchip by using a functionalized silane compound selfassembled monolayer. Two demonstrations for bacteria and explosives were examined by atomic force microscopy and x-ray photoelectron spectroscopy. It was found that 1H, 1H, 2H, 2HPerfluorooctyltriethoxysilane self-assembled monolayer on PDMS effectively blocked the nonspecific adsorption of Escherichia coli (O157:H7) and explosives such as 2, 4, 6-trinitrotoluene and 1, 3, 5-trinitroperhydro-1,3,5-triazine (RDX, Research Department Explosive).

Original languageEnglish
Article number013012
JournalJournal of Micro/Nanolithography, MEMS, and MOEMS
Issue number1
Publication statusPublished - Jan 1 2010


All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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