Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones

Akinori Hirashima; Manabu Matsushita; Hiroto Ohta; Kentaro Nakazono; Eiichi Kuwano; Morifusa Eto

doi:10.1016/j.pestbp.2005.09.005

Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones

Akinori Hirashima, Manabu Matsushita, Hiroto Ohta, Kentaro Nakazono, Eiichi Kuwano, Morifusa Eto

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	Pesticide Biochemistry and Physiology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/j.pestbp.2005.09.005
Publication status	Published - May 1 2006
Externally published	Yes

All Science Journal Classification (ASJC) codes

Agronomy and Crop Science
Health, Toxicology and Mutagenesis

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title = "Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones",

abstract = "Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.",

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AU - Hirashima, Akinori

AU - Matsushita, Manabu

AU - Ohta, Hiroto

AU - Nakazono, Kentaro

AU - Kuwano, Eiichi

AU - Eto, Morifusa

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.

AB - Effects of 1-arylimidazole-2(3H)-thiones (AITs) and 1-(substituted benzyl)imidazole-2(3H)-thiones (BITs) were tested on progeny formation in Drosophila melanogaster. Some AITs showed inhibitory activities at laying eggs and delayed eclosion by 1 day. The inhibitory activity was nullified by adding octopamine (OA) or noradrenaline (NA) to the medium for progeny formation in D. melanogaster. The effect of AIT on the contents of OA and NA was analyzed in adults of D. melanogaster by high-performance liquid chromatography with electrochemical detection. Flies fed with AIT decreased OA and NA levels and increased TA content. Taken together, the inhibitory activity of AIT could be due to inhibition of tyramine β-hydroxylase and dopamine β-hydroxylase.

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Prevention of progeny formation in Drosophila melanogaster by 1-arylimidazole-2(3H)-thiones

Abstract

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