Prevention of the incidence of diabetes by dietary sorbose in nonobese diabetic mice

Mitsuhiro Furuse, C. Kimura, H. Takahashi, J. I. Okumura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effect of dietary sorbose on the prevention of the incidence of diabetes in the nonobese diabetic mouse was investigated in animals from 5 to 11 wk of age. When sucrose (200 g/kg diet) in the control diet was replaced by sorbose, body weight was significantly reduced. The blood glucose level also was lowered in mice fed sorbose, but the serum insulin level was unchanged. Glucose was not detected in the urine of mice fed the sorbose diet during the experiment, but some mice in the control group excreted glucose in urine. Relative weights of the heart, liver and left kidney were significantly higher in mice fed the sorbose diet vs. those fed the control diet. The results suggest that dietary sorbose would benefit patients with diabetes by lowering blood glucose and inhibiting urinary glucose excretion.

Original languageEnglish
Pages (from-to)1135-1138
Number of pages4
JournalJournal of Nutrition
Volume121
Issue number7
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

Fingerprint

Sorbose
Inbred NOD Mouse
Diet
Incidence
Glucose
Blood Glucose
Urine
Sucrose
Body Weight
Insulin
Kidney
Weights and Measures
Control Groups
Liver
Serum

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Prevention of the incidence of diabetes by dietary sorbose in nonobese diabetic mice. / Furuse, Mitsuhiro; Kimura, C.; Takahashi, H.; Okumura, J. I.

In: Journal of Nutrition, Vol. 121, No. 7, 01.01.1991, p. 1135-1138.

Research output: Contribution to journalArticle

Furuse, Mitsuhiro ; Kimura, C. ; Takahashi, H. ; Okumura, J. I. / Prevention of the incidence of diabetes by dietary sorbose in nonobese diabetic mice. In: Journal of Nutrition. 1991 ; Vol. 121, No. 7. pp. 1135-1138.
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