Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity

K. Takayama, Yoichi Nakanishi, K. Takano, Taishi Harada, K. Inoue, S. Osaki, T. Minami, N. Hara

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume26
Issue number4
Publication statusPublished - Jan 1 1999

Fingerprint

Alprostadil
Cisplatin
beta 2-Microglobulin
Drug Therapy
Acetylglucosaminidase
Creatinine
Phlebitis
Blood Urea Nitrogen
Lung Neoplasms
Urine
Serum
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Takayama, K., Nakanishi, Y., Takano, K., Harada, T., Inoue, K., Osaki, S., ... Hara, N. (1999). Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity. Gan to kagaku ryoho. Cancer & chemotherapy, 26(4), 503-508.

Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity. / Takayama, K.; Nakanishi, Yoichi; Takano, K.; Harada, Taishi; Inoue, K.; Osaki, S.; Minami, T.; Hara, N.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 26, No. 4, 01.01.1999, p. 503-508.

Research output: Contribution to journalArticle

Takayama, K, Nakanishi, Y, Takano, K, Harada, T, Inoue, K, Osaki, S, Minami, T & Hara, N 1999, 'Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 26, no. 4, pp. 503-508.
Takayama K, Nakanishi Y, Takano K, Harada T, Inoue K, Osaki S et al. Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity. Gan to kagaku ryoho. Cancer & chemotherapy. 1999 Jan 1;26(4):503-508.
Takayama, K. ; Nakanishi, Yoichi ; Takano, K. ; Harada, Taishi ; Inoue, K. ; Osaki, S. ; Minami, T. ; Hara, N. / Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity. In: Gan to kagaku ryoho. Cancer & chemotherapy. 1999 ; Vol. 26, No. 4. pp. 503-508.
@article{9e4a932dc66c4a45823dda574cc07db1,
title = "Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity",
abstract = "In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity.",
author = "K. Takayama and Yoichi Nakanishi and K. Takano and Taishi Harada and K. Inoue and S. Osaki and T. Minami and N. Hara",
year = "1999",
month = "1",
day = "1",
language = "English",
volume = "26",
pages = "503--508",
journal = "Japanese Journal of Cancer and Chemotherapy",
issn = "0385-0684",
publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",
number = "4",

}

TY - JOUR

T1 - Preventive effect of prostaglandin E1 on cisplatin-induced nephrotoxicity

AU - Takayama, K.

AU - Nakanishi, Yoichi

AU - Takano, K.

AU - Harada, Taishi

AU - Inoue, K.

AU - Osaki, S.

AU - Minami, T.

AU - Hara, N.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity.

AB - In order to prevent the nephrotoxicity induced by cisplatin (CDDP), prostaglandin E1 (PGE1) was administered intravenously after anticancer chemotherapy to six patients with lung cancer. All patients underwent two courses of multi-drug chemotherapy with the same regimen including a single administration of 80 mg/m2 CDDP. From the 7th day of the 2nd course of chemotherapy, 120 micrograms PGE1 had been administered for five days. During the two courses of chemotherapy, serum creatinine, blood urea nitrogen, creatinine clearance (Ccr), 24-h excretions of beta 2-microglobulin (beta 2-MG) and N-acetylglucosaminidase (NAG) in urine were measured every week in all patients. The mean value of Ccr was higher in the 2nd course than in the control course (65 ml/min vs. 74 ml/min). The 24-h excretions of beta 2-MG and NAG were also reduced in the 2nd course. Out of six patients, only one was complicated by mild phlebitis at the PGE1 infusion site. From these results it was suggested that PGE1 was effective for prevention of CDDP nephrotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=0033086991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033086991&partnerID=8YFLogxK

M3 - Article

C2 - 10097747

AN - SCOPUS:0033086991

VL - 26

SP - 503

EP - 508

JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

SN - 0385-0684

IS - 4

ER -