A 71-year-old Japanese woman had two dome-shaped tumors on her right buttock with several surrounding papules. Histological examination revealed that large anaplastic cells and atypical lymphoid cells densely infiltrated the entire dermis. On immunohistochemical examination, Ki-1, HLA-DR. CD25 (IL-2 receptor α), CD122 (IL-2 receptor β). CD4. CD1 lc and CD68 were all positive in the tumor cells, whereas CDIa, CD3, CD5. CD8 and CD 19 were negative. Neither rearrangement of the T-cell receptor β. T-cell receptor γ nor the immunoglobulin heavy-chain was seen. Ultrastructurally, most of the tumor cells contained thick bundles of intermediate filaments in the perinuclear cytoplasm. Thus, this patient was diagnosed as having Ki-1-positive lymphoma of non-T. non-B origin. No recurrence or metastasis of the tumor has been observed in the last 2 years, although surgical resection was required 3 times before control was achieved.
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