Primary hepatic gastrointestinal stromal tumor showing remarkable myxoid change and hemangiopericytoma-like pattern

Hiroko Hayashi, Masachika Iseki, Masahiro Kawabata, Masaaki Nonoshita, Hidetaka Yamamoto, Isao Shimokawa

Research output: Contribution to journalArticle

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Abstract

Gastrointestinal stromal tumors (GISTs) in the liver are exceedingly rare. We report a case of hepatic GIST with myxoid changes and hemangiopericytoma-like patterns. A 69-year-old woman presented with epigastric discomfort, and underwent laparotomy for an extruded tumor in the liver. Five years later, recurrent tumor was excised. The primary tumor contained extensive necrotic and myxoid areas. Spindle and epithelioid cells plus a few giant cells with abundant myxoid matrix surrounded the necrotic areas. Immunohistochemically, the spindle cells were distinctly positive for KIT as well as vimentin and smooth muscle actin, leading to a diagnosis of hepatic GIST. The second excised tumor showed increased cellularity and nuclear atypia of epithelioid cells with hemangiopericytoma-like patterns. Although rare, we should consider GIST as a differential diagnosis for a hepatic mesenchymal tumor.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalActa Medica Nagasakiensia
Volume58
Issue number1
Publication statusPublished - 2013

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Hemangiopericytoma
Gastrointestinal Stromal Tumors
Liver
Epithelioid Cells
Neoplasms
Vimentin
Giant Cells
Laparotomy
Smooth Muscle
Actins
Differential Diagnosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Primary hepatic gastrointestinal stromal tumor showing remarkable myxoid change and hemangiopericytoma-like pattern. / Hayashi, Hiroko; Iseki, Masachika; Kawabata, Masahiro; Nonoshita, Masaaki; Yamamoto, Hidetaka; Shimokawa, Isao.

In: Acta Medica Nagasakiensia, Vol. 58, No. 1, 2013, p. 19-24.

Research output: Contribution to journalArticle

Hayashi, Hiroko ; Iseki, Masachika ; Kawabata, Masahiro ; Nonoshita, Masaaki ; Yamamoto, Hidetaka ; Shimokawa, Isao. / Primary hepatic gastrointestinal stromal tumor showing remarkable myxoid change and hemangiopericytoma-like pattern. In: Acta Medica Nagasakiensia. 2013 ; Vol. 58, No. 1. pp. 19-24.
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