Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome.

Eriko Sada, Motoaki Shiratsuchi, Junnichi Kiyasu, Kensaku Idutsu, Rie Ohtsuka, Eriko Nagasawa, Kennosuke Karube, Ryoichi Takayanagi, Yasunobu Abe

Research output: Contribution to journalReview article

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Abstract

A 20-year-old man with a primary non-seminomatous mediastinal germ cell tumor (yolk sac tumor and immature teratoma) developed hemophagocytic syndrome (HPS) three months after surgical resection. Around the same time, the patient was found to have bone metastases of the germ cell tumor. No other hereditary or acquired diseases related to HPS were found. The thrombocytopenia was refractory to corticosteroid therapy but improved after chemotherapy performed for germ cell tumor progression. Only three cases of germ cell tumor associated with reactive hemophagocytosis have been previously reported. Successful treatment of the present case by chemotherapy for HPS suggests a close relationship between this rare complication and germ cell tumor.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalJournal of clinical and experimental hematopathology : JCEH
Volume49
Issue number2
DOIs
Publication statusPublished - Jan 1 2009

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Hemophagocytic Lymphohistiocytosis
Germ Cell and Embryonal Neoplasms
Endodermal Sinus Tumor
Drug Therapy
Teratoma
Thrombocytopenia
Adrenal Cortex Hormones
Neoplasm Metastasis
Bone and Bones
Nonseminomatous germ cell tumor
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome. / Sada, Eriko; Shiratsuchi, Motoaki; Kiyasu, Junnichi; Idutsu, Kensaku; Ohtsuka, Rie; Nagasawa, Eriko; Karube, Kennosuke; Takayanagi, Ryoichi; Abe, Yasunobu.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 49, No. 2, 01.01.2009, p. 117-120.

Research output: Contribution to journalReview article

Sada, Eriko ; Shiratsuchi, Motoaki ; Kiyasu, Junnichi ; Idutsu, Kensaku ; Ohtsuka, Rie ; Nagasawa, Eriko ; Karube, Kennosuke ; Takayanagi, Ryoichi ; Abe, Yasunobu. / Primary mediastinal non-seminomatous germ cell tumor associated with hemophagocytic syndrome. In: Journal of clinical and experimental hematopathology : JCEH. 2009 ; Vol. 49, No. 2. pp. 117-120.
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AU - Sada, Eriko

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AU - Kiyasu, Junnichi

AU - Idutsu, Kensaku

AU - Ohtsuka, Rie

AU - Nagasawa, Eriko

AU - Karube, Kennosuke

AU - Takayanagi, Ryoichi

AU - Abe, Yasunobu

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