Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation

Hikaru Sakamoto; Hidehiro Itonaga; Yasushi Sawayama; Jun Taguchi; Tomomi Saijo; Sayaka Kuwatsuka; Mikiko Hashisako; Naoe Kinoshita; Masao Oishi; Hanako Doi; Kosuke Kosai; Katsutaro Nishimoto; Katsumi Tanaka; Katsunori Yanagihara; Hiroshi Mukae; Koichi Izumikawa; Yasushi Miyazaki

doi:10.2169/internalmedicine.0474-17

Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation

Hikaru Sakamoto, Hidehiro Itonaga, Yasushi Sawayama, Jun Taguchi, Tomomi Saijo, Sayaka Kuwatsuka, Mikiko Hashisako, Naoe Kinoshita, Masao Oishi, Hanako Doi, Kosuke Kosai, Katsutaro Nishimoto, Katsumi Tanaka, Katsunori Yanagihara, Hiroshi Mukae, Koichi Izumikawa, Yasushi Miyazaki

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.

Original language	English
Pages (from-to)	2567-2571
Number of pages	5
Journal	Internal Medicine
Volume	57
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.0474-17
Publication status	Published - 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

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Sakamoto, H., Itonaga, H., Sawayama, Y., Taguchi, J., Saijo, T., Kuwatsuka, S., Hashisako, M., Kinoshita, N., Oishi, M., Doi, H., Kosai, K., Nishimoto, K., Tanaka, K., Yanagihara, K., Mukae, H., Izumikawa, K., & Miyazaki, Y. (2018). Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation. Internal Medicine, 57(17), 2567-2571. https://doi.org/10.2169/internalmedicine.0474-17

Sakamoto, H, Itonaga, H, Sawayama, Y, Taguchi, J, Saijo, T, Kuwatsuka, S, Hashisako, M, Kinoshita, N, Oishi, M, Doi, H, Kosai, K, Nishimoto, K, Tanaka, K, Yanagihara, K, Mukae, H, Izumikawa, K & Miyazaki, Y 2018, 'Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation', Internal Medicine, vol. 57, no. 17, pp. 2567-2571. https://doi.org/10.2169/internalmedicine.0474-17

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title = "Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation",

abstract = "We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.",

author = "Hikaru Sakamoto and Hidehiro Itonaga and Yasushi Sawayama and Jun Taguchi and Tomomi Saijo and Sayaka Kuwatsuka and Mikiko Hashisako and Naoe Kinoshita and Masao Oishi and Hanako Doi and Kosuke Kosai and Katsutaro Nishimoto and Katsumi Tanaka and Katsunori Yanagihara and Hiroshi Mukae and Koichi Izumikawa and Yasushi Miyazaki",

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year = "2018",

doi = "10.2169/internalmedicine.0474-17",

language = "English",

volume = "57",

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AU - Sakamoto, Hikaru

AU - Itonaga, Hidehiro

AU - Sawayama, Yasushi

AU - Taguchi, Jun

AU - Saijo, Tomomi

AU - Kuwatsuka, Sayaka

AU - Hashisako, Mikiko

AU - Kinoshita, Naoe

AU - Oishi, Masao

AU - Doi, Hanako

AU - Kosai, Kosuke

AU - Nishimoto, Katsutaro

AU - Tanaka, Katsumi

AU - Yanagihara, Katsunori

AU - Mukae, Hiroshi

AU - Izumikawa, Koichi

AU - Miyazaki, Yasushi

PY - 2018

Y1 - 2018

N2 - We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.

AB - We herein report a rare case of oral mucormycosis following allogeneic hematopoietic stem cell transplantation. Oral mucormycosis due to Rhizopus microsporus manifested as localized left buccal mucositis with a 1-cm black focus before neutrophil recovery. Combination therapy with liposomal amphotericin B was initiated and surgical debridement was performed; however, the patient died due to progressive generalized mucormycosis. Considerable attention needs to be paid to the diagnosis and management of oral mucormycosis in post-transplant patients, thereby suggesting the importance of fully understanding the risk factors.

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JF - Internal Medicine

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Primary oral mucormycosis due to rhizopus microsporus after allogeneic stem cell transplantation

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