Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literature.

Katsumi Harimaya, Yoshinao Oda, Shuichi Matsuda, Kazuhiro Tanaka, Hirokazu Chuman, Yukihide Iwamoto

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

STUDY DESIGN: Report of four cases and a review of the literature. OBJECTIVES: To study the clinical features and prognosis of primitive neuroectodermal tumor or extraskeletal Ewing sarcoma arising around the spinal column. SUMMARY OF BACKGROUND DATA: Primitive neuroectodermal tumor or extraskeletal Ewing sarcoma that originates around the spinal column is very rare, and its prognosis is very poor. METHODS: Four patients were diagnosed and underwent treatment. RESULTS: Although all the patients received high-dose chemotherapy with or without radiotherapy after surgery, three patients died of the disease. Only one patient who received en bloc resection of the tumor combined with multiagent chemotherapy followed by high-dose chemotherapy with peripheral blood stem cell transplantation remains alive and continues to be disease free. CONCLUSION: The prognosis of the patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column is very poor. Multiagent chemotherapy combined with en bloc resection and radiation therapy is the preferred treatment for patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column.

Original languageEnglish
Pages (from-to)E408-412
JournalSpine
Volume28
Issue number19
Publication statusPublished - Oct 1 2003

Fingerprint

Primitive Neuroectodermal Tumors
Ewing's Sarcoma
Spine
Drug Therapy
Radiotherapy
Peripheral Blood Stem Cell Transplantation
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column : report of four cases and a review of the literature. / Harimaya, Katsumi; Oda, Yoshinao; Matsuda, Shuichi; Tanaka, Kazuhiro; Chuman, Hirokazu; Iwamoto, Yukihide.

In: Spine, Vol. 28, No. 19, 01.10.2003, p. E408-412.

Research output: Contribution to journalReview article

@article{6180b1d2800d4947862710b18f24b07d,
title = "Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literature.",
abstract = "STUDY DESIGN: Report of four cases and a review of the literature. OBJECTIVES: To study the clinical features and prognosis of primitive neuroectodermal tumor or extraskeletal Ewing sarcoma arising around the spinal column. SUMMARY OF BACKGROUND DATA: Primitive neuroectodermal tumor or extraskeletal Ewing sarcoma that originates around the spinal column is very rare, and its prognosis is very poor. METHODS: Four patients were diagnosed and underwent treatment. RESULTS: Although all the patients received high-dose chemotherapy with or without radiotherapy after surgery, three patients died of the disease. Only one patient who received en bloc resection of the tumor combined with multiagent chemotherapy followed by high-dose chemotherapy with peripheral blood stem cell transplantation remains alive and continues to be disease free. CONCLUSION: The prognosis of the patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column is very poor. Multiagent chemotherapy combined with en bloc resection and radiation therapy is the preferred treatment for patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column.",
author = "Katsumi Harimaya and Yoshinao Oda and Shuichi Matsuda and Kazuhiro Tanaka and Hirokazu Chuman and Yukihide Iwamoto",
year = "2003",
month = "10",
day = "1",
language = "English",
volume = "28",
pages = "E408--412",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams and Wilkins",
number = "19",

}

TY - JOUR

T1 - Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column

T2 - report of four cases and a review of the literature.

AU - Harimaya, Katsumi

AU - Oda, Yoshinao

AU - Matsuda, Shuichi

AU - Tanaka, Kazuhiro

AU - Chuman, Hirokazu

AU - Iwamoto, Yukihide

PY - 2003/10/1

Y1 - 2003/10/1

N2 - STUDY DESIGN: Report of four cases and a review of the literature. OBJECTIVES: To study the clinical features and prognosis of primitive neuroectodermal tumor or extraskeletal Ewing sarcoma arising around the spinal column. SUMMARY OF BACKGROUND DATA: Primitive neuroectodermal tumor or extraskeletal Ewing sarcoma that originates around the spinal column is very rare, and its prognosis is very poor. METHODS: Four patients were diagnosed and underwent treatment. RESULTS: Although all the patients received high-dose chemotherapy with or without radiotherapy after surgery, three patients died of the disease. Only one patient who received en bloc resection of the tumor combined with multiagent chemotherapy followed by high-dose chemotherapy with peripheral blood stem cell transplantation remains alive and continues to be disease free. CONCLUSION: The prognosis of the patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column is very poor. Multiagent chemotherapy combined with en bloc resection and radiation therapy is the preferred treatment for patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column.

AB - STUDY DESIGN: Report of four cases and a review of the literature. OBJECTIVES: To study the clinical features and prognosis of primitive neuroectodermal tumor or extraskeletal Ewing sarcoma arising around the spinal column. SUMMARY OF BACKGROUND DATA: Primitive neuroectodermal tumor or extraskeletal Ewing sarcoma that originates around the spinal column is very rare, and its prognosis is very poor. METHODS: Four patients were diagnosed and underwent treatment. RESULTS: Although all the patients received high-dose chemotherapy with or without radiotherapy after surgery, three patients died of the disease. Only one patient who received en bloc resection of the tumor combined with multiagent chemotherapy followed by high-dose chemotherapy with peripheral blood stem cell transplantation remains alive and continues to be disease free. CONCLUSION: The prognosis of the patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column is very poor. Multiagent chemotherapy combined with en bloc resection and radiation therapy is the preferred treatment for patients with primitive neuroectodermal tumor or extraskeletal Ewing sarcoma around the spinal column.

UR - http://www.scopus.com/inward/record.url?scp=4944232238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4944232238&partnerID=8YFLogxK

M3 - Review article

C2 - 14520055

AN - SCOPUS:4944232238

VL - 28

SP - E408-412

JO - Spine

JF - Spine

SN - 0362-2436

IS - 19

ER -