Problems and prospects for combined chemotherapy with 5-fluorouracil and low-dose cisplatin

Hitoshi Kusaba, K. Mitsugi, S. Nakano, N. Saijo

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Recently, the efficacy of combined chemotherapy with 5-fluorouracil and low-dose cisplatin for advanced gastrointestinal cancer has been reported in Japan. However, this method has not become established, because the underlying logic is unclear and the quality of its clinical trials has been unsatisfactory. We suggest the mechanism for this depends not only on the action of CDDP as a modulator of 5-FU, but also on a mutual biochemical modulation in which 5-FU acts as a modulator of CDDP and enhances the effect of CDDP. We expect that numerous phase II studies and the accumulation of reliable data will lead to improvements.

Original languageEnglish
Pages (from-to)1575-1580
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume26
Issue number11
Publication statusPublished - Jan 1 1999
Externally publishedYes

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Fluorouracil
Cisplatin
Drug Therapy
Gastrointestinal Neoplasms
Japan
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Problems and prospects for combined chemotherapy with 5-fluorouracil and low-dose cisplatin. / Kusaba, Hitoshi; Mitsugi, K.; Nakano, S.; Saijo, N.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 26, No. 11, 01.01.1999, p. 1575-1580.

Research output: Contribution to journalReview article

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