Production of a recombinant human monoclonal antibody using a novel hollow fiber bioreactor system

Yuichi Inoue, Seiji Kawamoto, Kiyohiko Seki, Kiichiro Teruya, Katsumi Mochizuki, Masatoshi Kato, Shuichi Hashizume, Kosei Yasumoto, Akira Nagashima, Hisashi Nakahashi, Tatsuo Suzuki, Tadaaki Imai, Kikuo Nomoto, Sanetaka Shirahata

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3 Citations (Scopus)

Abstract

The amplified ras oncogene was used to enhance the productivity of BHK-21 cells producing a lung cancer-reactive human recombinant AE6F4 monoclonal antibody. The recombinant antibody (18 mg) was produced by the ras-amplified BHK-21 cells in a one-month high-density culture using the novel hollow fiber bioreactor system Tecnomouse.

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalJournal of Fermentation and Bioengineering
Volume81
Issue number5
DOIs
Publication statusPublished - Jan 1 1996

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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