Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit

H. Masaki, T. Imaizumi, S. Ando, Yoshitaka Hirooka, S. Harada, M. Momohara, M. Nagano, A. Takeshita

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing

Original languageEnglish
Pages (from-to)828-831
Number of pages4
JournalCardiovascular research
Volume27
Issue number5
Publication statusPublished - Jan 1 1993

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Heart Failure
Rabbits
Central Venous Pressure
Thiamylal
Weights and Measures
Pleural Effusion
Thoracotomy
Ascites
Cardiac Output
Heart Ventricles
Norepinephrine
Electrodes
Anesthesia
Hemodynamics
Body Weight
Blood Pressure
Light
Lung

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Masaki, H., Imaizumi, T., Ando, S., Hirooka, Y., Harada, S., Momohara, M., ... Takeshita, A. (1993). Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit. Cardiovascular research, 27(5), 828-831.

Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit. / Masaki, H.; Imaizumi, T.; Ando, S.; Hirooka, Yoshitaka; Harada, S.; Momohara, M.; Nagano, M.; Takeshita, A.

In: Cardiovascular research, Vol. 27, No. 5, 01.01.1993, p. 828-831.

Research output: Contribution to journalArticle

Masaki, H, Imaizumi, T, Ando, S, Hirooka, Y, Harada, S, Momohara, M, Nagano, M & Takeshita, A 1993, 'Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit', Cardiovascular research, vol. 27, no. 5, pp. 828-831.
Masaki H, Imaizumi T, Ando S, Hirooka Y, Harada S, Momohara M et al. Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit. Cardiovascular research. 1993 Jan 1;27(5):828-831.
Masaki, H. ; Imaizumi, T. ; Ando, S. ; Hirooka, Yoshitaka ; Harada, S. ; Momohara, M. ; Nagano, M. ; Takeshita, A. / Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit. In: Cardiovascular research. 1993 ; Vol. 27, No. 5. pp. 828-831.
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abstract = "Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing",
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AU - Masaki, H.

AU - Imaizumi, T.

AU - Ando, S.

AU - Hirooka, Yoshitaka

AU - Harada, S.

AU - Momohara, M.

AU - Nagano, M.

AU - Takeshita, A.

PY - 1993/1/1

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N2 - Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing

AB - Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing

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