Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit

H. Masaki, T. Imaizumi, S. Ando, Yoshitaka Hirooka, S. Harada, M. Momohara, M. Nagano, A. Takeshita

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    Objective: The aim was to produce a model of low output congestive heart failure by rapid pacing in rabbits. Methods: To perform rapid pacing in rabbits, a custom made pacemaker was developed which is light (about 80 g) and can pace at up to 400 beats · min-1 for more than two weeks. A thoracotomy was done and two electrodes were sutured onto the left ventricle. A central venous pressure line was chronically implanted. With the use of this pacemaker, rabbits were paced at 350-400 beats · min-1 for several weeks. Results: Central venous pressure increased from 1.4(SEM 0.2) to 6.4(0.5) mm Hg (p < 0.01, n = 14). After pacing for 16.1(1.6) d, haemodynamic studies were performed under anaesthesia with thiamylal sodium. Left ventricular end diastolic pressure was higher in the paced rabbits (n = 10) than in the control rabbits which underwent sham operation but were not paced (n = 6), at -0.6(0.6) v 19.3(2.0) mm Hg (p < 0.01). Cardiac output [673(56) v 536(45) ml · min-1, p < 0.10] and +dP/dt [1433(97) v 722(51) mm Hg · s-1, p < 0.01] were lower in the paced rabbits (n = 7-8) than in the control rabbits (n = 6). The paced rabbits had more ascites [1.9(1.0) v 45.9(18.9) ml, p < 0.05] and pleural effusion [0.4(0.3) v 12.9(6.7) ml, p < 0.10] than control rabbits. Plasma noradrenaline was higher in the paced rabbits (n = 11) than in the control rabbits (n = 7), at 1.59(0.43) v 0.60(0.05) ng · ml-1 (p < 0.05). The ratio of wet heart weight or lung weight to body weight was higher (p < 0.01) in the paced rabbits than in the control rabbits. Conclusions: Chronic biventricular congestive heart failure can be produced in rabbits by rapid pacing

    Original languageEnglish
    Pages (from-to)828-831
    Number of pages4
    JournalCardiovascular research
    Volume27
    Issue number5
    Publication statusPublished - Jan 1 1993

    All Science Journal Classification (ASJC) codes

    • Physiology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Fingerprint Dive into the research topics of 'Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit'. Together they form a unique fingerprint.

    Cite this