Production of daunorubicin by immobilized growing Streptomyces peucetius cells

Yoshiki Takashima, Hiroki Nakajima, Kenji Sonomoto, Atsuo Tanaka

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Streptomyces peucetius cells were immobilized by entrapment in calcium alginate and a photosensitive synthetic polymer, and used for the production of daunorubicin (daunomycin), which is known to be an antitumour reagent. The use of cultivation media removed insoluble components in a natural medium prevented rapid decrease in daunorubicin titer after maximum production. These entrapped cells could be used at least five times for repeated daunorubicin production; the total cultivation period was 45 days.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalApplied Microbiology and Biotechnology
Volume27
Issue number2
DOIs
Publication statusPublished - Nov 1 1987

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Daunorubicin
Streptomyces
Immobilized Cells
Polymers

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Production of daunorubicin by immobilized growing Streptomyces peucetius cells. / Takashima, Yoshiki; Nakajima, Hiroki; Sonomoto, Kenji; Tanaka, Atsuo.

In: Applied Microbiology and Biotechnology, Vol. 27, No. 2, 01.11.1987, p. 106-109.

Research output: Contribution to journalArticle

Takashima, Yoshiki ; Nakajima, Hiroki ; Sonomoto, Kenji ; Tanaka, Atsuo. / Production of daunorubicin by immobilized growing Streptomyces peucetius cells. In: Applied Microbiology and Biotechnology. 1987 ; Vol. 27, No. 2. pp. 106-109.
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