Production of IL-4, IL-2, IFN-γ, and TNF-α by peripheral blood mononuclear cells of patients with atopic dermatitis

Takenori Takahashi, Yutaroh Sasaki, Kazuaki Hama, Masutaka Furue, Yasumasa Ishibashi

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Recently, T cell-derived cytokines have been postulated to be involved in the pathogenesis of atopic dermatitis (AD) since the synthesis of IgE is profoundly regulated by cytokines such as IL-4, IFN-γ and IL-2 IL-4 enhances the production of IgE and in contrast, IFN-γ inhibits this IL-4-mediated IgE production. IL-2 also prevents IL-4-induced production of IgE by a different mechanism from IFN-γ, suggesting that the level of IgE is regulated by the quantitative balance of these antagonizing cytokines. We examined the production of IL-4, IL-2, IFN-γ and TNF-α by PBMC of AD patients and non-AD controls. Although the production of IL-2 and TNF-α by AD patients was significantly lower than that of non-AD controls, the production of IL-4 and IFN-γ did not show significant differences between AD and non-AD individuals. There was no significant correlation between cytokine production and clinical symptoms in AD patients. There was significant positive correlation between IL-4 and IL-2 production, and between IFN-γ and TNF-α production. Serum IL-4 levels showed no significant difference between AD group and non-AD group.

Original languageEnglish
Pages (from-to)172-180
Number of pages9
JournalJournal of Dermatological Science
Issue number3
Publication statusPublished - May 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology


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