Prognosis and therapeutic response according to the World Health Organization histological classification in advanced thymoma

Tetsuzo Tagawa, Takuro Kometani, Koji Yamazaki, Tatsuro Okamoto, Hiroshi Wataya, Takashi Seto, Seiichi Fukuyama, Atsushi Osoegawa, Fumihiko Hirai, Kenji Sugio, Yukito Ichinose

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Purpose: The clinical efficacy of the World Health Organization (WHO) classification of thymoma has been reported to be a prognostic factor for patients with thymomas. This study focuses on the relationship between the therapeutic response and the WHO histological classification in patients with advanced thymoma. Methods: A retrospective review was performed on 22 patients with Masaoka stage III and IV thymoma treated from 1975 to 2007. There were 1, 1, 7, 3, and 10 patients with WHO histological subtypes A, AB, B1, B2, and B3, respectively. Results: Surgery was performed on 10 patients. There were 2 complete resections, 2 incomplete resections, and 6 exploratory thoracotomies. Of 18 patients with unresectable tumors, 8, 5, and 5 were treated with radiotherapy, chemotherapy, and chemoradiotherapy as the initial therapy, respectively. The response rate in 9 patients with type A-B2 was significantly better than that in 9 patients with type B3 regardless of treatment modality (100% vs 11.1%, P = 0.0001). Only the WHO classification was significantly associated with survival, with type B3 having a worse prognosis than A-B2 (P = 0.01). Conclusions: Type B3 thymoma showed a lower response rate to treatments and thus shorter survival. The WHO classification is a good predictive factor for therapeutic response in advanced thymoma.

Original languageEnglish
Pages (from-to)1599-1604
Number of pages6
JournalSurgery today
Volume41
Issue number12
DOIs
Publication statusPublished - Dec 1 2011

All Science Journal Classification (ASJC) codes

  • Surgery

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