Prognostic factors for chronic active Epstein-Barr virus infection

Hiroshi Kimura, Tsuneo Morishima, Hirokazu Kanegane, Shouichi Ohga, Yo Hoshino, Akihiko Maeda, Shosuke Imai, Motohiko Okano, Tomohiro Morio, Shumpei Yokota, Shigeru Tsuchiya, Akihiro Yachie, Shinsaku Imashuku, Keisei Kawa, Hiroshi Wakiguchi

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169 Citations (Scopus)


Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-morbidity disease. To clarify the prognostic factors, a national survey was performed in Japan, and data for 82 patients who met the criteria for CAEBV were analyzed. Of these 82 patients, 47 were alive and 35 had already died. Multivariate analysis revealed that thromobocytopenia and age at disease onset were correlated with mortality. The probability of 5-year survival was 0.45 for older patients (onset age, ≥8 years), 0.94 for younger patients (P<.001), 0.38 for patients with thrombocytopenia (platelet count <12 × 104 platelets/μL at diagnosis), and 0.76 for patients without thrombocytopenia (P = .01). Furthermore, patients with T cell infection by EBV had shorter survival times than patients with natural killer cell infection (probability of 5-year survival, 0.59 vs. 0.87; P<.009). Patients with CAEBV with late onset of disease, thrombocytopenia, and T cell infection had significantly poorer outcomes.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalJournal of Infectious Diseases
Issue number4
Publication statusPublished - Feb 15 2003

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases


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