Prognostic factors for survival after resection of pulmonary metastases from colorectal carcinoma

Atsushi Osoegawa, Takuro Kometani, Seiichi Fukuyama, Fumihiko Hirai, Takashi Seto, Kenji Sugio, Yukito Ichinose

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: As chemotherapy has improved, the survival of patients with metastatic colorectal carcinoma has reached up to 2.5 years. Many of these patients experience pulmonary metastases; however, the prognosis after pulmonary metastasectomy is not satisfying. In this study, we analyzed the prognostic factors for survival in patients who underwent pulmonary metastasectomy. Methods: Eighty-seven patients with colorectal carcinoma received pulmonary metastasectomy. The pathological status of the primary tumor, outcome of the pulmonary metastasectomy, disease-free interval, perioperative carcinoembryonic antigen (CEA) level and history of liver metastases were assessed. Results: The five-year survival was 42.5% after pulmonary metastasectomy. A univariate analyses revealed that the CEA level (p = 0.043) and the number of pulmonary metastases (p = 0.047) were prognostic factors for survival. The CEA level was an independent prognostic factor in a multivariate analysis (relative risk = 2.01, p = 0.037). Among cases with elevated preoperative CEA levels, those whose CEA level normalized after metastasectomy had a better prognosis compared with those whose CEA level decreased but was still high, or whose level increased after metastasectomy (median survival time of 41.8 months compared with 28.1 or 15.7 months, respectively p = 0.021). Conclusion: The CEA level can be a predictive marker for the prognosis in patients with pulmonary metastases from colorectal carcinoma.

Original languageEnglish
Pages (from-to)6-11
Number of pages6
JournalAnnals of Thoracic and Cardiovascular Surgery
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 20 2016

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Metastasectomy
Carcinoembryonic Antigen
Colorectal Neoplasms
Neoplasm Metastasis
Lung
Survival
Lung Diseases
Multivariate Analysis
Drug Therapy
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Gastroenterology

Cite this

Prognostic factors for survival after resection of pulmonary metastases from colorectal carcinoma. / Osoegawa, Atsushi; Kometani, Takuro; Fukuyama, Seiichi; Hirai, Fumihiko; Seto, Takashi; Sugio, Kenji; Ichinose, Yukito.

In: Annals of Thoracic and Cardiovascular Surgery, Vol. 22, No. 1, 20.02.2016, p. 6-11.

Research output: Contribution to journalArticle

Osoegawa, Atsushi ; Kometani, Takuro ; Fukuyama, Seiichi ; Hirai, Fumihiko ; Seto, Takashi ; Sugio, Kenji ; Ichinose, Yukito. / Prognostic factors for survival after resection of pulmonary metastases from colorectal carcinoma. In: Annals of Thoracic and Cardiovascular Surgery. 2016 ; Vol. 22, No. 1. pp. 6-11.
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AU - Sugio, Kenji

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