Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis

Ken Shirabe, Mitsuo Shimada, Eiji Tsujita, Shin Ichi Aishima, Shin Ichiroh Maehara, Sinji Tanaka, Kenji Takenaka, Yoshihiko Maehara

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Abstract

Background The aim of this study was to clarify prognostic factors and recurrence patterns in patients with node-negative intrahepatic cholangiocarcinoma (IHCC). Methods A retrospective study was performed to review prognostic factors and recurrence patterns (1) in 22 patients with node-negative IHCC after curative hepatic resection and (2) in 49 patients who underwent resection and lymph node dissection for IHCC. In addition to determining the clinicopathologic factors, the investigators also performed immunohistochemical examination of microvessel counts using antihuman CD-31 and antibody. Results The significant poor prognostic factors in node-negative IHCC were the presence of intrahepatic metastasis, portal vein invasion of cancer cells, and high microvessel counts. After multivariate analysis was conducted, the independent poor prognostic factors were the presence of intrahepatic metastases and high microvessel counts. Of 9 patients who had postoperative recurrence of their disease, intrahepatic recurrence was observed in 7 (78 %). Conclusions The factors linked to poor prognosis in IHCC were tumor angiogenesis and the presence of intrahepatic metastasis. Because intrahepatic recurrence was common, regional and adjuvant chemotherapy to the liver may improve the outcome of patients with these risk factors and node-negative IHCC.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalAmerican Journal of Surgery
Volume187
Issue number4
DOIs
Publication statusPublished - Apr 2004

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Cholangiocarcinoma
Recurrence
Microvessels
Neoplasm Metastasis
Liver
Adjuvant Chemotherapy
Portal Vein
Lymph Node Excision
Neoplasms
Multivariate Analysis
Retrospective Studies
Research Personnel
Antibodies

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Shirabe, K., Shimada, M., Tsujita, E., Aishima, S. I., Maehara, S. I., Tanaka, S., ... Maehara, Y. (2004). Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. American Journal of Surgery, 187(4), 538-542. https://doi.org/10.1016/j.amjsurg.2003.12.044

Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. / Shirabe, Ken; Shimada, Mitsuo; Tsujita, Eiji; Aishima, Shin Ichi; Maehara, Shin Ichiroh; Tanaka, Sinji; Takenaka, Kenji; Maehara, Yoshihiko.

In: American Journal of Surgery, Vol. 187, No. 4, 04.2004, p. 538-542.

Research output: Contribution to journalArticle

Shirabe, K, Shimada, M, Tsujita, E, Aishima, SI, Maehara, SI, Tanaka, S, Takenaka, K & Maehara, Y 2004, 'Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis', American Journal of Surgery, vol. 187, no. 4, pp. 538-542. https://doi.org/10.1016/j.amjsurg.2003.12.044
Shirabe, Ken ; Shimada, Mitsuo ; Tsujita, Eiji ; Aishima, Shin Ichi ; Maehara, Shin Ichiroh ; Tanaka, Sinji ; Takenaka, Kenji ; Maehara, Yoshihiko. / Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. In: American Journal of Surgery. 2004 ; Vol. 187, No. 4. pp. 538-542.
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