Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy

Koji Yamazaki, Kenji Sugio, Takeharu Yamanaka, Fumihiko Hirai, Atsushi Osoegawa, Tetsuzo Tagawa, Seiichi Fukuyama, Hiroshi Wataya, Takashi Seto, Yukito Ichinose

Research output: Contribution to journalArticle

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Abstract

Aim: To analyse the prognostic factors for patients with non-small cell lung cancer (NSCLC) who underwent cytotoxic chemotherapy with third generation agents or epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrence. Patients and Methods: Between 1997 and 2005, 479 patients underwent a complete resection for NSCLC. Of these, 112 patients underwent chemotherapy for postoperative recurrence. Results: Median postrecurrence survival time for these 112 patients was 25.6 months. Univariate analysis showed female gender, age younger than 65 years, ECOG performance status of 0-I, never-smoker status, and adenocarcinoma prolonged survival, whereas metastasis to the liver or adrenal gland shortened survival. Multivariate analysis revealed age, performance status, cell type and metastasis to the adrenal gland to be independent prognostic factors. Conclusion: Age, performance status, cell type, and metastasis to the adrenal were independent prognostic factors in NSCLC patients treated with third-generation agents or EGFR-TKI for recurrence.

Original languageEnglish
Pages (from-to)1311-1315
Number of pages5
JournalAnticancer research
Volume30
Issue number4
Publication statusPublished - Apr 1 2010

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Non-Small Cell Lung Carcinoma
Recurrence
Drug Therapy
Adrenal Glands
Neoplasm Metastasis
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Survival
Adenocarcinoma
Multivariate Analysis
Liver

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy. / Yamazaki, Koji; Sugio, Kenji; Yamanaka, Takeharu; Hirai, Fumihiko; Osoegawa, Atsushi; Tagawa, Tetsuzo; Fukuyama, Seiichi; Wataya, Hiroshi; Seto, Takashi; Ichinose, Yukito.

In: Anticancer research, Vol. 30, No. 4, 01.04.2010, p. 1311-1315.

Research output: Contribution to journalArticle

Yamazaki, K, Sugio, K, Yamanaka, T, Hirai, F, Osoegawa, A, Tagawa, T, Fukuyama, S, Wataya, H, Seto, T & Ichinose, Y 2010, 'Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy', Anticancer research, vol. 30, no. 4, pp. 1311-1315.
Yamazaki, Koji ; Sugio, Kenji ; Yamanaka, Takeharu ; Hirai, Fumihiko ; Osoegawa, Atsushi ; Tagawa, Tetsuzo ; Fukuyama, Seiichi ; Wataya, Hiroshi ; Seto, Takashi ; Ichinose, Yukito. / Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy. In: Anticancer research. 2010 ; Vol. 30, No. 4. pp. 1311-1315.
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AU - Osoegawa, Atsushi

AU - Tagawa, Tetsuzo

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AU - Wataya, Hiroshi

AU - Seto, Takashi

AU - Ichinose, Yukito

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N2 - Aim: To analyse the prognostic factors for patients with non-small cell lung cancer (NSCLC) who underwent cytotoxic chemotherapy with third generation agents or epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrence. Patients and Methods: Between 1997 and 2005, 479 patients underwent a complete resection for NSCLC. Of these, 112 patients underwent chemotherapy for postoperative recurrence. Results: Median postrecurrence survival time for these 112 patients was 25.6 months. Univariate analysis showed female gender, age younger than 65 years, ECOG performance status of 0-I, never-smoker status, and adenocarcinoma prolonged survival, whereas metastasis to the liver or adrenal gland shortened survival. Multivariate analysis revealed age, performance status, cell type and metastasis to the adrenal gland to be independent prognostic factors. Conclusion: Age, performance status, cell type, and metastasis to the adrenal were independent prognostic factors in NSCLC patients treated with third-generation agents or EGFR-TKI for recurrence.

AB - Aim: To analyse the prognostic factors for patients with non-small cell lung cancer (NSCLC) who underwent cytotoxic chemotherapy with third generation agents or epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrence. Patients and Methods: Between 1997 and 2005, 479 patients underwent a complete resection for NSCLC. Of these, 112 patients underwent chemotherapy for postoperative recurrence. Results: Median postrecurrence survival time for these 112 patients was 25.6 months. Univariate analysis showed female gender, age younger than 65 years, ECOG performance status of 0-I, never-smoker status, and adenocarcinoma prolonged survival, whereas metastasis to the liver or adrenal gland shortened survival. Multivariate analysis revealed age, performance status, cell type and metastasis to the adrenal gland to be independent prognostic factors. Conclusion: Age, performance status, cell type, and metastasis to the adrenal were independent prognostic factors in NSCLC patients treated with third-generation agents or EGFR-TKI for recurrence.

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