Prognostic factors in patients with idiopathic portal hypertension: Two Japanese nationwide epidemiological surveys in 1999 and 2005

Yoko Murai, Satoko Ohfuji, Wakaba Fukushima, Akiko Tamakoshi, Shohei Yamaguchi, Makoto Hashizume, Fuminori Moriyasu, Yoshio Hirota

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: To investigate factors affecting disease prognosis among patients with idiopathic portal hypertension (IPH). Methods: Two Japanese nationwide epidemiological surveys on IPH were conducted in 1999 and 2005. Analyzing data from each cross-sectional survey separately, we examined the consistent prognostic factors detected from each analysis and assessed the effect of treatments for varices on IPH prognosis. Outcome was the disease condition at last observation compared with that at diagnosis, categorized into two levels (recovered/improved and unchanged/aggravated/deceased). To evaluate the association with each characteristic, we calculated adjusted odds ratio (OR) and 95% confidence interval (CI) using a binary model for logistic regression. Results: Among 160 patients with IPH in 1999 and 85 in 2005, 10% had aggravated disease at a mean of 6-7years after the diagnosis. Statistically significant ORs were observed for two factors: esophageal varices, especially of F2-3 stage, at diagnosis (OR=6.83, 95% CI=2.10-22.1 in 1999; OR=10.7, 95% CI=1.08-105 in 2005) ameliorated IPH; and hepatic encephalopathy at diagnosis (OR=0.19, 95% CI=0.03-1.04 in 1999; crude OR=0.05, 95% CI=0.01-0.60 in 2005 using a proportional odds model) worsened IPH. Further analyses explained that the apparent ameliorating effect of esophageal varices was due to the effect of subsequent treatment (OR=4.59, 95% CI=0.89-23.7 in 2005). Conclusion: The prognosis of IPH would be better if varices were adequately controlled. Patients with liver failure at diagnosis would be at high risk for subsequent disease aggravation.

Original languageEnglish
Pages (from-to)1211-1220
Number of pages10
JournalHepatology Research
Volume42
Issue number12
DOIs
Publication statusPublished - Dec 1 2012

Fingerprint

Odds Ratio
Confidence Intervals
Esophageal and Gastric Varices
Varicose Veins
Hepatic Encephalopathy
Liver Failure
Surveys and Questionnaires
Banti's syndrome
Cross-Sectional Studies
Logistic Models
Observation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

Cite this

Prognostic factors in patients with idiopathic portal hypertension : Two Japanese nationwide epidemiological surveys in 1999 and 2005. / Murai, Yoko; Ohfuji, Satoko; Fukushima, Wakaba; Tamakoshi, Akiko; Yamaguchi, Shohei; Hashizume, Makoto; Moriyasu, Fuminori; Hirota, Yoshio.

In: Hepatology Research, Vol. 42, No. 12, 01.12.2012, p. 1211-1220.

Research output: Contribution to journalArticle

Murai, Y, Ohfuji, S, Fukushima, W, Tamakoshi, A, Yamaguchi, S, Hashizume, M, Moriyasu, F & Hirota, Y 2012, 'Prognostic factors in patients with idiopathic portal hypertension: Two Japanese nationwide epidemiological surveys in 1999 and 2005', Hepatology Research, vol. 42, no. 12, pp. 1211-1220. https://doi.org/10.1111/j.1872-034X.2012.01033.x
Murai, Yoko ; Ohfuji, Satoko ; Fukushima, Wakaba ; Tamakoshi, Akiko ; Yamaguchi, Shohei ; Hashizume, Makoto ; Moriyasu, Fuminori ; Hirota, Yoshio. / Prognostic factors in patients with idiopathic portal hypertension : Two Japanese nationwide epidemiological surveys in 1999 and 2005. In: Hepatology Research. 2012 ; Vol. 42, No. 12. pp. 1211-1220.
@article{3434cd4c830e490fa207b9418569f77c,
title = "Prognostic factors in patients with idiopathic portal hypertension: Two Japanese nationwide epidemiological surveys in 1999 and 2005",
abstract = "Aim: To investigate factors affecting disease prognosis among patients with idiopathic portal hypertension (IPH). Methods: Two Japanese nationwide epidemiological surveys on IPH were conducted in 1999 and 2005. Analyzing data from each cross-sectional survey separately, we examined the consistent prognostic factors detected from each analysis and assessed the effect of treatments for varices on IPH prognosis. Outcome was the disease condition at last observation compared with that at diagnosis, categorized into two levels (recovered/improved and unchanged/aggravated/deceased). To evaluate the association with each characteristic, we calculated adjusted odds ratio (OR) and 95{\%} confidence interval (CI) using a binary model for logistic regression. Results: Among 160 patients with IPH in 1999 and 85 in 2005, 10{\%} had aggravated disease at a mean of 6-7years after the diagnosis. Statistically significant ORs were observed for two factors: esophageal varices, especially of F2-3 stage, at diagnosis (OR=6.83, 95{\%} CI=2.10-22.1 in 1999; OR=10.7, 95{\%} CI=1.08-105 in 2005) ameliorated IPH; and hepatic encephalopathy at diagnosis (OR=0.19, 95{\%} CI=0.03-1.04 in 1999; crude OR=0.05, 95{\%} CI=0.01-0.60 in 2005 using a proportional odds model) worsened IPH. Further analyses explained that the apparent ameliorating effect of esophageal varices was due to the effect of subsequent treatment (OR=4.59, 95{\%} CI=0.89-23.7 in 2005). Conclusion: The prognosis of IPH would be better if varices were adequately controlled. Patients with liver failure at diagnosis would be at high risk for subsequent disease aggravation.",
author = "Yoko Murai and Satoko Ohfuji and Wakaba Fukushima and Akiko Tamakoshi and Shohei Yamaguchi and Makoto Hashizume and Fuminori Moriyasu and Yoshio Hirota",
year = "2012",
month = "12",
day = "1",
doi = "10.1111/j.1872-034X.2012.01033.x",
language = "English",
volume = "42",
pages = "1211--1220",
journal = "Hepatology Research",
issn = "1386-6346",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Prognostic factors in patients with idiopathic portal hypertension

T2 - Two Japanese nationwide epidemiological surveys in 1999 and 2005

AU - Murai, Yoko

AU - Ohfuji, Satoko

AU - Fukushima, Wakaba

AU - Tamakoshi, Akiko

AU - Yamaguchi, Shohei

AU - Hashizume, Makoto

AU - Moriyasu, Fuminori

AU - Hirota, Yoshio

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Aim: To investigate factors affecting disease prognosis among patients with idiopathic portal hypertension (IPH). Methods: Two Japanese nationwide epidemiological surveys on IPH were conducted in 1999 and 2005. Analyzing data from each cross-sectional survey separately, we examined the consistent prognostic factors detected from each analysis and assessed the effect of treatments for varices on IPH prognosis. Outcome was the disease condition at last observation compared with that at diagnosis, categorized into two levels (recovered/improved and unchanged/aggravated/deceased). To evaluate the association with each characteristic, we calculated adjusted odds ratio (OR) and 95% confidence interval (CI) using a binary model for logistic regression. Results: Among 160 patients with IPH in 1999 and 85 in 2005, 10% had aggravated disease at a mean of 6-7years after the diagnosis. Statistically significant ORs were observed for two factors: esophageal varices, especially of F2-3 stage, at diagnosis (OR=6.83, 95% CI=2.10-22.1 in 1999; OR=10.7, 95% CI=1.08-105 in 2005) ameliorated IPH; and hepatic encephalopathy at diagnosis (OR=0.19, 95% CI=0.03-1.04 in 1999; crude OR=0.05, 95% CI=0.01-0.60 in 2005 using a proportional odds model) worsened IPH. Further analyses explained that the apparent ameliorating effect of esophageal varices was due to the effect of subsequent treatment (OR=4.59, 95% CI=0.89-23.7 in 2005). Conclusion: The prognosis of IPH would be better if varices were adequately controlled. Patients with liver failure at diagnosis would be at high risk for subsequent disease aggravation.

AB - Aim: To investigate factors affecting disease prognosis among patients with idiopathic portal hypertension (IPH). Methods: Two Japanese nationwide epidemiological surveys on IPH were conducted in 1999 and 2005. Analyzing data from each cross-sectional survey separately, we examined the consistent prognostic factors detected from each analysis and assessed the effect of treatments for varices on IPH prognosis. Outcome was the disease condition at last observation compared with that at diagnosis, categorized into two levels (recovered/improved and unchanged/aggravated/deceased). To evaluate the association with each characteristic, we calculated adjusted odds ratio (OR) and 95% confidence interval (CI) using a binary model for logistic regression. Results: Among 160 patients with IPH in 1999 and 85 in 2005, 10% had aggravated disease at a mean of 6-7years after the diagnosis. Statistically significant ORs were observed for two factors: esophageal varices, especially of F2-3 stage, at diagnosis (OR=6.83, 95% CI=2.10-22.1 in 1999; OR=10.7, 95% CI=1.08-105 in 2005) ameliorated IPH; and hepatic encephalopathy at diagnosis (OR=0.19, 95% CI=0.03-1.04 in 1999; crude OR=0.05, 95% CI=0.01-0.60 in 2005 using a proportional odds model) worsened IPH. Further analyses explained that the apparent ameliorating effect of esophageal varices was due to the effect of subsequent treatment (OR=4.59, 95% CI=0.89-23.7 in 2005). Conclusion: The prognosis of IPH would be better if varices were adequately controlled. Patients with liver failure at diagnosis would be at high risk for subsequent disease aggravation.

UR - http://www.scopus.com/inward/record.url?scp=84870273265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870273265&partnerID=8YFLogxK

U2 - 10.1111/j.1872-034X.2012.01033.x

DO - 10.1111/j.1872-034X.2012.01033.x

M3 - Article

C2 - 22583903

AN - SCOPUS:84870273265

VL - 42

SP - 1211

EP - 1220

JO - Hepatology Research

JF - Hepatology Research

SN - 1386-6346

IS - 12

ER -