Prognostic factors in patients with submucosal carcinoma of the oesophagus

M. Watanabe, H. Kuwano, K. Araki, H. Kawaguchi, H. Saeki, K. Kitamura, S. Ohno, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

To clarify the prognostic factors in patients with submucosal carcinoma of the oesophagus, we examined the results of surgical treatment for 78 cases over the last decade. The clinicopathological factors including age, sex, location of the tumour, length of the tumour, histological difterentiation, subclassification of depth, lymphatic or blood vessel invasion, intramural metastasis and lymph node metastasis were all analysed. Then the correlation between these factors and prognosis was investigated. As a result, significant differences were observed in the survival rates between the groups regarding lymphatic vessel invasion (P = 0.0003), intramural metastasis (P = 0.0051) and lymph node metastasis (P= 0.0026). According to a multivariate analysis, intramural metastasis (P = 0.0038, relative risk 9.17), vessel invasion (P= 0.0033, relative risk 6.25) and lymph node metastasis (P= 0.0187, relative risk 3.62) were found to be independent prognostic factors. The prognosis of the patients with at least one of these factors was significantly poorer than that without. The five-year survival rate of the patients without these factors was as good as that with mucosal carcinoma of the oesophagus. Based on our findings, vessel invasion, intramural metastasis and lymph node metastasis are thus considered to be significant prognostic factors in patients with submucosal carcinoma of the oesophagus. (C) 2000 Cancer Research Campaign.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalBritish journal of cancer
Volume83
Issue number5
Publication statusPublished - Aug 31 2000

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Esophagus
Neoplasm Metastasis
Carcinoma
Lymph Nodes
Lymphatic Vessels
Survival Rate
Age Factors
Blood Vessels
Neoplasms
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Watanabe, M., Kuwano, H., Araki, K., Kawaguchi, H., Saeki, H., Kitamura, K., ... Sugimachi, K. (2000). Prognostic factors in patients with submucosal carcinoma of the oesophagus. British journal of cancer, 83(5), 609-613.

Prognostic factors in patients with submucosal carcinoma of the oesophagus. / Watanabe, M.; Kuwano, H.; Araki, K.; Kawaguchi, H.; Saeki, H.; Kitamura, K.; Ohno, S.; Sugimachi, K.

In: British journal of cancer, Vol. 83, No. 5, 31.08.2000, p. 609-613.

Research output: Contribution to journalArticle

Watanabe, M, Kuwano, H, Araki, K, Kawaguchi, H, Saeki, H, Kitamura, K, Ohno, S & Sugimachi, K 2000, 'Prognostic factors in patients with submucosal carcinoma of the oesophagus', British journal of cancer, vol. 83, no. 5, pp. 609-613.
Watanabe M, Kuwano H, Araki K, Kawaguchi H, Saeki H, Kitamura K et al. Prognostic factors in patients with submucosal carcinoma of the oesophagus. British journal of cancer. 2000 Aug 31;83(5):609-613.
Watanabe, M. ; Kuwano, H. ; Araki, K. ; Kawaguchi, H. ; Saeki, H. ; Kitamura, K. ; Ohno, S. ; Sugimachi, K. / Prognostic factors in patients with submucosal carcinoma of the oesophagus. In: British journal of cancer. 2000 ; Vol. 83, No. 5. pp. 609-613.
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