Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

Keita Terui, Tomoaki Taguchi, Keiji Goishi, Masahiro Hayakawa, Yuko Tazuke, Akiko Yokoi, Hajime Takayasu, Hiroomi Okuyama, Hideo Yoshida, Noriaki Usui

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.Methods: The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.

Original languageEnglish
Pages (from-to)1129-1134
Number of pages6
JournalPediatric surgery international
Volume30
Issue number11
DOIs
Publication statusPublished - Jan 1 2014

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Gastroesophageal Reflux
Multicenter Studies
Enteral Nutrition
Weaning
Gestational Age
Therapeutics
Congenital Diaphragmatic Hernias
Survival Analysis
Observational Studies
Retrospective Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia : a multicenter study. / Terui, Keita; Taguchi, Tomoaki; Goishi, Keiji; Hayakawa, Masahiro; Tazuke, Yuko; Yokoi, Akiko; Takayasu, Hajime; Okuyama, Hiroomi; Yoshida, Hideo; Usui, Noriaki.

In: Pediatric surgery international, Vol. 30, No. 11, 01.01.2014, p. 1129-1134.

Research output: Contribution to journalArticle

Terui, K, Taguchi, T, Goishi, K, Hayakawa, M, Tazuke, Y, Yokoi, A, Takayasu, H, Okuyama, H, Yoshida, H & Usui, N 2014, 'Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study', Pediatric surgery international, vol. 30, no. 11, pp. 1129-1134. https://doi.org/10.1007/s00383-014-3594-7
Terui, Keita ; Taguchi, Tomoaki ; Goishi, Keiji ; Hayakawa, Masahiro ; Tazuke, Yuko ; Yokoi, Akiko ; Takayasu, Hajime ; Okuyama, Hiroomi ; Yoshida, Hideo ; Usui, Noriaki. / Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia : a multicenter study. In: Pediatric surgery international. 2014 ; Vol. 30, No. 11. pp. 1129-1134.
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abstract = "Purpose: Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.Methods: The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 {\%} (40/168), and were completed in 60.0 {\%} (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 {\%} CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 {\%} (18/169). Gestational age (HR 4.78, 95 {\%} CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 {\%} (HR 4.3, 95 {\%} CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 {\%} (40/168), and were completed in 60.0 {\%} (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 {\%} CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 {\%} (18/169). Gestational age (HR 4.78, 95 {\%} CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 {\%} (HR 4.3, 95 {\%} CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.",
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T1 - Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia

T2 - a multicenter study

AU - Terui, Keita

AU - Taguchi, Tomoaki

AU - Goishi, Keiji

AU - Hayakawa, Masahiro

AU - Tazuke, Yuko

AU - Yokoi, Akiko

AU - Takayasu, Hajime

AU - Okuyama, Hiroomi

AU - Yoshida, Hideo

AU - Usui, Noriaki

PY - 2014/1/1

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N2 - Purpose: Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.Methods: The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.

AB - Purpose: Gastroesophageal reflux disease (GERD) is one of the concomitant problems in infants with congenital diaphragmatic hernia (CDH). We assessed risk factors of GERD in CDH patients.Methods: The retrospective observational study for CDH infants was conducted. Cases of CDH who were born between January 2006 and December 2010, were operated in the 9 participating institutions, and survived to discharge were included. Completion of medical therapy for GERD and incidence of surgery were primary outcomes. Kaplan–Meier survival analysis and Cox proportional hazards regression were used.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.Results: In 182 cases of CDH, the medical therapies for GERD were performed in 23.8 % (40/168), and were completed in 60.0 % (24/40). Prenatal detection of CDH (HR 5.87, CI 1.6–18.8, p = 0.012) and tube feeding at discharge (HR 5.04, 95 % CI 1.3–33.1, p = 0.016) were significantly correlated with unsuccessful weaning from medical therapy. Surgery for GERD was performed in 10.7 % (18/169). Gestational age (HR 4.78, 95 % CI 1.5–21.1, p = 0.006) and diaphragmatic defect of more than 75 % (HR 4.3, 95 % CI 1.6–12.9, p = 0.005) were significantly correlated with need for antireflux surgery.

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