Prognostic factors of node-negative gastric carcinoma: Univariate and multivariate analyses

Y. Adachi, M. Mori, Yoshihiko Maehara, S. Kitano, K. Sugimachi

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

BACKGROUND: The presence or absence of lymph node metastasis closely correlates with survival of patients with gastric carcinoma. Although prognostic significance of the number and level of lymph node metastasis has been clarified, clinicopathologic features and prognostic indicators of node- negative gastric carcinoma have not yet been studied. STUDY DESIGN: The records of 435 patients who underwent curative D2 or D3 gastrectomy for gastric carcinoma between 1977 and 1987 were analyzed retrospectively. Clinicopathologic data of 252 patients having no lymph node metastasis were compared with those of 183 patients with lymph node metastasis. Prognostic factors were investigated by univariate and multivariate analyses. RESULTS: Compared with node-positive cases, node-negative cases were characterized by frequent location in the lower two thirds of the stomach (85 percent), tumor size less than 4 cm (54 percent), grossly superficial type (69 percent), and tumor invasion not beyond the muscularis propria (77 percent). The 10-year- survival rate for patients with node-negative tumors was 93.4 percent. Multivariate analysis demonstrated that depth of wall invasion and age of patient were independent prognostic factors. CONCLUSIONS: Node-negative gastric carcinoma is associated with a favorable outcome because of small progression of the disease. The depth of wall invasion and patient age were the most important prognostic factors.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalJournal of the American College of Surgeons
Volume184
Issue number4
Publication statusPublished - May 3 1997

Fingerprint

Stomach
Multivariate Analysis
Carcinoma
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Gastrectomy
Disease Progression
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Prognostic factors of node-negative gastric carcinoma : Univariate and multivariate analyses. / Adachi, Y.; Mori, M.; Maehara, Yoshihiko; Kitano, S.; Sugimachi, K.

In: Journal of the American College of Surgeons, Vol. 184, No. 4, 03.05.1997, p. 373-377.

Research output: Contribution to journalArticle

Adachi, Y. ; Mori, M. ; Maehara, Yoshihiko ; Kitano, S. ; Sugimachi, K. / Prognostic factors of node-negative gastric carcinoma : Univariate and multivariate analyses. In: Journal of the American College of Surgeons. 1997 ; Vol. 184, No. 4. pp. 373-377.
@article{bc586680eaa44c989a1bad00007aba4c,
title = "Prognostic factors of node-negative gastric carcinoma: Univariate and multivariate analyses",
abstract = "BACKGROUND: The presence or absence of lymph node metastasis closely correlates with survival of patients with gastric carcinoma. Although prognostic significance of the number and level of lymph node metastasis has been clarified, clinicopathologic features and prognostic indicators of node- negative gastric carcinoma have not yet been studied. STUDY DESIGN: The records of 435 patients who underwent curative D2 or D3 gastrectomy for gastric carcinoma between 1977 and 1987 were analyzed retrospectively. Clinicopathologic data of 252 patients having no lymph node metastasis were compared with those of 183 patients with lymph node metastasis. Prognostic factors were investigated by univariate and multivariate analyses. RESULTS: Compared with node-positive cases, node-negative cases were characterized by frequent location in the lower two thirds of the stomach (85 percent), tumor size less than 4 cm (54 percent), grossly superficial type (69 percent), and tumor invasion not beyond the muscularis propria (77 percent). The 10-year- survival rate for patients with node-negative tumors was 93.4 percent. Multivariate analysis demonstrated that depth of wall invasion and age of patient were independent prognostic factors. CONCLUSIONS: Node-negative gastric carcinoma is associated with a favorable outcome because of small progression of the disease. The depth of wall invasion and patient age were the most important prognostic factors.",
author = "Y. Adachi and M. Mori and Yoshihiko Maehara and S. Kitano and K. Sugimachi",
year = "1997",
month = "5",
day = "3",
language = "English",
volume = "184",
pages = "373--377",
journal = "Journal of the American College of Surgeons",
issn = "1072-7515",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Prognostic factors of node-negative gastric carcinoma

T2 - Univariate and multivariate analyses

AU - Adachi, Y.

AU - Mori, M.

AU - Maehara, Yoshihiko

AU - Kitano, S.

AU - Sugimachi, K.

PY - 1997/5/3

Y1 - 1997/5/3

N2 - BACKGROUND: The presence or absence of lymph node metastasis closely correlates with survival of patients with gastric carcinoma. Although prognostic significance of the number and level of lymph node metastasis has been clarified, clinicopathologic features and prognostic indicators of node- negative gastric carcinoma have not yet been studied. STUDY DESIGN: The records of 435 patients who underwent curative D2 or D3 gastrectomy for gastric carcinoma between 1977 and 1987 were analyzed retrospectively. Clinicopathologic data of 252 patients having no lymph node metastasis were compared with those of 183 patients with lymph node metastasis. Prognostic factors were investigated by univariate and multivariate analyses. RESULTS: Compared with node-positive cases, node-negative cases were characterized by frequent location in the lower two thirds of the stomach (85 percent), tumor size less than 4 cm (54 percent), grossly superficial type (69 percent), and tumor invasion not beyond the muscularis propria (77 percent). The 10-year- survival rate for patients with node-negative tumors was 93.4 percent. Multivariate analysis demonstrated that depth of wall invasion and age of patient were independent prognostic factors. CONCLUSIONS: Node-negative gastric carcinoma is associated with a favorable outcome because of small progression of the disease. The depth of wall invasion and patient age were the most important prognostic factors.

AB - BACKGROUND: The presence or absence of lymph node metastasis closely correlates with survival of patients with gastric carcinoma. Although prognostic significance of the number and level of lymph node metastasis has been clarified, clinicopathologic features and prognostic indicators of node- negative gastric carcinoma have not yet been studied. STUDY DESIGN: The records of 435 patients who underwent curative D2 or D3 gastrectomy for gastric carcinoma between 1977 and 1987 were analyzed retrospectively. Clinicopathologic data of 252 patients having no lymph node metastasis were compared with those of 183 patients with lymph node metastasis. Prognostic factors were investigated by univariate and multivariate analyses. RESULTS: Compared with node-positive cases, node-negative cases were characterized by frequent location in the lower two thirds of the stomach (85 percent), tumor size less than 4 cm (54 percent), grossly superficial type (69 percent), and tumor invasion not beyond the muscularis propria (77 percent). The 10-year- survival rate for patients with node-negative tumors was 93.4 percent. Multivariate analysis demonstrated that depth of wall invasion and age of patient were independent prognostic factors. CONCLUSIONS: Node-negative gastric carcinoma is associated with a favorable outcome because of small progression of the disease. The depth of wall invasion and patient age were the most important prognostic factors.

UR - http://www.scopus.com/inward/record.url?scp=0030935046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030935046&partnerID=8YFLogxK

M3 - Article

C2 - 9100682

AN - SCOPUS:0030935046

VL - 184

SP - 373

EP - 377

JO - Journal of the American College of Surgeons

JF - Journal of the American College of Surgeons

SN - 1072-7515

IS - 4

ER -