Prognostic impact of albumin-bilirubin (ALBI) grade on non-small lung cell carcinoma: A propensity-score matched analysis

Fumihiko Kinoshita, Takanori Yamashita, Yuka Oku, Keisuke Kosai, Yuki Ono, Sho Wakasu, Naoki Haratake, Gouji Toyokawa, Tomoyoshi Takenaka, Tetsuzo Tagawa, Mototsugu Shimokawa, Naoki Nakashima, Masaki Mori

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Albumin-bilirubin (ALBI) grade is an indicator of liver dysfunction and is useful for predicting postoperative prognosis of hepatocellular carcinomas. However, the significance of ALBI grade in non-small cell lung carcinoma (NSCLC) has not been elucidated. Patients and Methods: We analyzed 947 patients with pStage IA-IIIA NSCLC. We divided patients into ALBI grade 1 and grade 2/3 groups. We then analyzed the association of ABLI grade with clinicopathological characteristics and prognosis in NSCLC by using propensity-score matching. Results: ALBI grade 2/3 was significantly associated with older age, male sex, advanced pT status, and histological type. Even after propensity-score matching, ALBI grade 2/3 patients had significantly worse cancer-specific survival (CSS) than ALBI grade 1 patients (5-year CSS: 87.3% versus 92.8%; p=0.0247). In multivariate analysis, ALBI grade 2/3 was an independent predictor of CSS (HR=1.9; 95%CI=1.11-3.11; p=0.0177). Conclusion: ALBI grade was an independent prognostic factor in surgically resected NSCLC.

Original languageEnglish
Pages (from-to)1621-1628
Number of pages8
JournalAnticancer research
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 2021

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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