Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer

Tatsuro Okamoto, Hironobu Wada, Teruaki Mizobuchi, Hidehisa Hoshino, Yasumitsu Moriya, Shigetoshi Yoshida, Ichiro Yoshino

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: We retrospectively investigated whether histological cell type could affect patient prognosis for each stage according to the seventh edition of the TNM classification. Patients and methods: Clinical records of 1623 consecutive non-small cell lung cancer patients who underwent surgery between 1990 and 2007 were retrospectively reviewed. Over 92% of these patients had either adenocarcinoma (Ad; n = 1043, 64.3%) or squamous cell carcinoma (Sq; n = 452, 27.9%). Results: The overall 5-year survival rates for patients of all stages with Ad, Sq, large cell carcinoma (La), and adenosquamous cell carcinoma (As) were 67%, 56%, 58%, and 41%, respectively. Ad patients experienced better survival than Sq, As, or La patients (HR: 0.66, P < 0.0001; HR: 0.38, P = 0.011; HR: 0.69, P = 0.057, respectively). Stage IA Ad patients experienced better survival than stage IA Sq patients (5-year survival; Ad/Sq = 91%/78%, log-rank test, P = 0.001). Such a difference was also observed among seventh-edition TNM stage IB patients (5-year survival; Ad/Sq = 78%/64%, log-rank test, P = 0.048), but not for sixth-edition stage IB patients. Multivariate analysis demonstrated that histological cell type is a significant prognostic factor among stage I ≥ T1b Ad and Sq patients. Conclusions: Survival after complete resection of new stage I ≥ T1b Sq patients is significantly worse than that of Ad patients, which could be partially attributed to stage migration effect in stage IB disease between the sixth and seventh editions of the TNM staging system.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalThoracic Cancer
Volume3
Issue number3
DOIs
Publication statusPublished - Aug 1 2012

Fingerprint

Neoplasm Staging
Non-Small Cell Lung Carcinoma
Survival
Exanthema Subitum
Adenosquamous Carcinoma
Large Cell Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Okamoto, T., Wada, H., Mizobuchi, T., Hoshino, H., Moriya, Y., Yoshida, S., & Yoshino, I. (2012). Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer. Thoracic Cancer, 3(3), 249-254. https://doi.org/10.1111/j.1759-7714.2012.00118.x

Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer. / Okamoto, Tatsuro; Wada, Hironobu; Mizobuchi, Teruaki; Hoshino, Hidehisa; Moriya, Yasumitsu; Yoshida, Shigetoshi; Yoshino, Ichiro.

In: Thoracic Cancer, Vol. 3, No. 3, 01.08.2012, p. 249-254.

Research output: Contribution to journalArticle

Okamoto, T, Wada, H, Mizobuchi, T, Hoshino, H, Moriya, Y, Yoshida, S & Yoshino, I 2012, 'Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer', Thoracic Cancer, vol. 3, no. 3, pp. 249-254. https://doi.org/10.1111/j.1759-7714.2012.00118.x
Okamoto, Tatsuro ; Wada, Hironobu ; Mizobuchi, Teruaki ; Hoshino, Hidehisa ; Moriya, Yasumitsu ; Yoshida, Shigetoshi ; Yoshino, Ichiro. / Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer. In: Thoracic Cancer. 2012 ; Vol. 3, No. 3. pp. 249-254.
@article{0573389f886c4dd1a8f2e2a85a6af6e7,
title = "Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer",
abstract = "Objectives: We retrospectively investigated whether histological cell type could affect patient prognosis for each stage according to the seventh edition of the TNM classification. Patients and methods: Clinical records of 1623 consecutive non-small cell lung cancer patients who underwent surgery between 1990 and 2007 were retrospectively reviewed. Over 92{\%} of these patients had either adenocarcinoma (Ad; n = 1043, 64.3{\%}) or squamous cell carcinoma (Sq; n = 452, 27.9{\%}). Results: The overall 5-year survival rates for patients of all stages with Ad, Sq, large cell carcinoma (La), and adenosquamous cell carcinoma (As) were 67{\%}, 56{\%}, 58{\%}, and 41{\%}, respectively. Ad patients experienced better survival than Sq, As, or La patients (HR: 0.66, P < 0.0001; HR: 0.38, P = 0.011; HR: 0.69, P = 0.057, respectively). Stage IA Ad patients experienced better survival than stage IA Sq patients (5-year survival; Ad/Sq = 91{\%}/78{\%}, log-rank test, P = 0.001). Such a difference was also observed among seventh-edition TNM stage IB patients (5-year survival; Ad/Sq = 78{\%}/64{\%}, log-rank test, P = 0.048), but not for sixth-edition stage IB patients. Multivariate analysis demonstrated that histological cell type is a significant prognostic factor among stage I ≥ T1b Ad and Sq patients. Conclusions: Survival after complete resection of new stage I ≥ T1b Sq patients is significantly worse than that of Ad patients, which could be partially attributed to stage migration effect in stage IB disease between the sixth and seventh editions of the TNM staging system.",
author = "Tatsuro Okamoto and Hironobu Wada and Teruaki Mizobuchi and Hidehisa Hoshino and Yasumitsu Moriya and Shigetoshi Yoshida and Ichiro Yoshino",
year = "2012",
month = "8",
day = "1",
doi = "10.1111/j.1759-7714.2012.00118.x",
language = "English",
volume = "3",
pages = "249--254",
journal = "Thoracic Cancer",
issn = "1759-7706",
publisher = "Blackwell Publishing Asia Pty Ltd",
number = "3",

}

TY - JOUR

T1 - Prognostic impact of cell type under the seventh TNM staging system in resected non-small cell lung cancer

AU - Okamoto, Tatsuro

AU - Wada, Hironobu

AU - Mizobuchi, Teruaki

AU - Hoshino, Hidehisa

AU - Moriya, Yasumitsu

AU - Yoshida, Shigetoshi

AU - Yoshino, Ichiro

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Objectives: We retrospectively investigated whether histological cell type could affect patient prognosis for each stage according to the seventh edition of the TNM classification. Patients and methods: Clinical records of 1623 consecutive non-small cell lung cancer patients who underwent surgery between 1990 and 2007 were retrospectively reviewed. Over 92% of these patients had either adenocarcinoma (Ad; n = 1043, 64.3%) or squamous cell carcinoma (Sq; n = 452, 27.9%). Results: The overall 5-year survival rates for patients of all stages with Ad, Sq, large cell carcinoma (La), and adenosquamous cell carcinoma (As) were 67%, 56%, 58%, and 41%, respectively. Ad patients experienced better survival than Sq, As, or La patients (HR: 0.66, P < 0.0001; HR: 0.38, P = 0.011; HR: 0.69, P = 0.057, respectively). Stage IA Ad patients experienced better survival than stage IA Sq patients (5-year survival; Ad/Sq = 91%/78%, log-rank test, P = 0.001). Such a difference was also observed among seventh-edition TNM stage IB patients (5-year survival; Ad/Sq = 78%/64%, log-rank test, P = 0.048), but not for sixth-edition stage IB patients. Multivariate analysis demonstrated that histological cell type is a significant prognostic factor among stage I ≥ T1b Ad and Sq patients. Conclusions: Survival after complete resection of new stage I ≥ T1b Sq patients is significantly worse than that of Ad patients, which could be partially attributed to stage migration effect in stage IB disease between the sixth and seventh editions of the TNM staging system.

AB - Objectives: We retrospectively investigated whether histological cell type could affect patient prognosis for each stage according to the seventh edition of the TNM classification. Patients and methods: Clinical records of 1623 consecutive non-small cell lung cancer patients who underwent surgery between 1990 and 2007 were retrospectively reviewed. Over 92% of these patients had either adenocarcinoma (Ad; n = 1043, 64.3%) or squamous cell carcinoma (Sq; n = 452, 27.9%). Results: The overall 5-year survival rates for patients of all stages with Ad, Sq, large cell carcinoma (La), and adenosquamous cell carcinoma (As) were 67%, 56%, 58%, and 41%, respectively. Ad patients experienced better survival than Sq, As, or La patients (HR: 0.66, P < 0.0001; HR: 0.38, P = 0.011; HR: 0.69, P = 0.057, respectively). Stage IA Ad patients experienced better survival than stage IA Sq patients (5-year survival; Ad/Sq = 91%/78%, log-rank test, P = 0.001). Such a difference was also observed among seventh-edition TNM stage IB patients (5-year survival; Ad/Sq = 78%/64%, log-rank test, P = 0.048), but not for sixth-edition stage IB patients. Multivariate analysis demonstrated that histological cell type is a significant prognostic factor among stage I ≥ T1b Ad and Sq patients. Conclusions: Survival after complete resection of new stage I ≥ T1b Sq patients is significantly worse than that of Ad patients, which could be partially attributed to stage migration effect in stage IB disease between the sixth and seventh editions of the TNM staging system.

UR - http://www.scopus.com/inward/record.url?scp=84864756331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864756331&partnerID=8YFLogxK

U2 - 10.1111/j.1759-7714.2012.00118.x

DO - 10.1111/j.1759-7714.2012.00118.x

M3 - Article

AN - SCOPUS:84864756331

VL - 3

SP - 249

EP - 254

JO - Thoracic Cancer

JF - Thoracic Cancer

SN - 1759-7706

IS - 3

ER -