Prognostic impact of geriatric nutritional risk index in patients with synchronous colorectal liver metastasis

Tomohiro Iguchi; Keishi Sugimachi; Yohei Mano; Takashi Motomura; Masahiko Sugiyama; Mitsuhiko Ota; Masahiko Ikebe; Taito Esaki; Tomoharu Yoshizumi; Masaru Morita; Masaki Mori; Yasushi Toh

doi:10.21873/ANTICANRES.14416

Prognostic impact of geriatric nutritional risk index in patients with synchronous colorectal liver metastasis

Tomohiro Iguchi, Keishi Sugimachi, Yohei Mano, Takashi Motomura, Masahiko Sugiyama, Mitsuhiko Ota, Masahiko Ikebe, Taito Esaki, Tomoharu Yoshizumi, Masaru Morita, Masaki Mori, Yasushi Toh

Surgery

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Abstract

Background/Aim: The Geriatric Nutritional Risk Index (GNRI) is a prognostic indicator for several cancers; however, the association between the GNRI and colorectal liver metastasis (CRLM) remains unknown. Patients and Methods: Eighty patients who underwent hepatectomy for synchronous CRLM were divided into two groups based on the GNRI. Results: The preoperative CA19-9 levels were significantly higher in the low (GNRI ≤98; n=30) than the normal GNRI group (GNRI >98; n=50). Patients in the low GNRI group had poorer outcomes than those in the normal GNRI group. A low GNRI was an independent prognostic factor for recurrence-free survival and overall survival. Among 50 patients who experienced recurrence, only 16 of 22 patients (72.7%) in the low GNRI group could receive intensive treatment and 27 of 28 patients (96.4%) in the normal GNRI group. Conclusion: The GNRI is a simplified prognostic factor for patients with CRLM.

Original language	English
Pages (from-to)	4165-4171
Number of pages	7
Journal	Anticancer research
Volume	40
Issue number	7
DOIs	https://doi.org/10.21873/ANTICANRES.14416
Publication status	Published - Jul 2020

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Oncology
Cancer Research

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10.21873/ANTICANRES.14416

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@article{532dc251b007454ab73ebda34d90aa03,

title = "Prognostic impact of geriatric nutritional risk index in patients with synchronous colorectal liver metastasis",

abstract = "Background/Aim: The Geriatric Nutritional Risk Index (GNRI) is a prognostic indicator for several cancers; however, the association between the GNRI and colorectal liver metastasis (CRLM) remains unknown. Patients and Methods: Eighty patients who underwent hepatectomy for synchronous CRLM were divided into two groups based on the GNRI. Results: The preoperative CA19-9 levels were significantly higher in the low (GNRI ≤98; n=30) than the normal GNRI group (GNRI >98; n=50). Patients in the low GNRI group had poorer outcomes than those in the normal GNRI group. A low GNRI was an independent prognostic factor for recurrence-free survival and overall survival. Among 50 patients who experienced recurrence, only 16 of 22 patients (72.7%) in the low GNRI group could receive intensive treatment and 27 of 28 patients (96.4%) in the normal GNRI group. Conclusion: The GNRI is a simplified prognostic factor for patients with CRLM.",

author = "Tomohiro Iguchi and Keishi Sugimachi and Yohei Mano and Takashi Motomura and Masahiko Sugiyama and Mitsuhiko Ota and Masahiko Ikebe and Taito Esaki and Tomoharu Yoshizumi and Masaru Morita and Masaki Mori and Yasushi Toh",

note = "Funding Information: This work was supported by the following grants and foundations: Grants-in-Aid for Scientific Research of MEXT/JSPS KAKENHI Grant Number JP 18K07222. Publisher Copyright: {\textcopyright} 2020 International Institute of Anticancer Research. All rights reserved.",

year = "2020",

month = jul,

doi = "10.21873/ANTICANRES.14416",

language = "English",

volume = "40",

pages = "4165--4171",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Prognostic impact of geriatric nutritional risk index in patients with synchronous colorectal liver metastasis

AU - Iguchi, Tomohiro

AU - Sugimachi, Keishi

AU - Mano, Yohei

AU - Motomura, Takashi

AU - Sugiyama, Masahiko

AU - Ota, Mitsuhiko

AU - Ikebe, Masahiko

AU - Esaki, Taito

AU - Yoshizumi, Tomoharu

AU - Morita, Masaru

AU - Mori, Masaki

AU - Toh, Yasushi

N1 - Funding Information: This work was supported by the following grants and foundations: Grants-in-Aid for Scientific Research of MEXT/JSPS KAKENHI Grant Number JP 18K07222. Publisher Copyright: © 2020 International Institute of Anticancer Research. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - Background/Aim: The Geriatric Nutritional Risk Index (GNRI) is a prognostic indicator for several cancers; however, the association between the GNRI and colorectal liver metastasis (CRLM) remains unknown. Patients and Methods: Eighty patients who underwent hepatectomy for synchronous CRLM were divided into two groups based on the GNRI. Results: The preoperative CA19-9 levels were significantly higher in the low (GNRI ≤98; n=30) than the normal GNRI group (GNRI >98; n=50). Patients in the low GNRI group had poorer outcomes than those in the normal GNRI group. A low GNRI was an independent prognostic factor for recurrence-free survival and overall survival. Among 50 patients who experienced recurrence, only 16 of 22 patients (72.7%) in the low GNRI group could receive intensive treatment and 27 of 28 patients (96.4%) in the normal GNRI group. Conclusion: The GNRI is a simplified prognostic factor for patients with CRLM.

AB - Background/Aim: The Geriatric Nutritional Risk Index (GNRI) is a prognostic indicator for several cancers; however, the association between the GNRI and colorectal liver metastasis (CRLM) remains unknown. Patients and Methods: Eighty patients who underwent hepatectomy for synchronous CRLM were divided into two groups based on the GNRI. Results: The preoperative CA19-9 levels were significantly higher in the low (GNRI ≤98; n=30) than the normal GNRI group (GNRI >98; n=50). Patients in the low GNRI group had poorer outcomes than those in the normal GNRI group. A low GNRI was an independent prognostic factor for recurrence-free survival and overall survival. Among 50 patients who experienced recurrence, only 16 of 22 patients (72.7%) in the low GNRI group could receive intensive treatment and 27 of 28 patients (96.4%) in the normal GNRI group. Conclusion: The GNRI is a simplified prognostic factor for patients with CRLM.

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Prognostic impact of geriatric nutritional risk index in patients with synchronous colorectal liver metastasis

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